Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We modified the rabbit model for enteric infection by Vibrio cholerae developed by Spira et al. and designated the RITARD (for removable intestinal tie-adult rabbit diarrhea) model (20). Our modification DISC comprises a permanent ligation of the cecum (C) to prevent resorption of the fluid secreted by the small intestine, a temporary ligation of the small intestine (S) to enable the bacteria to colonize, and duodenal inoculation (DI) of the challenge material. The main difference between RITARD and DISC is that in the latter model the challenge material is injected into the duodenum approximately 10 cm distal to the stomach instead of into the jejunum. Four out of 5 V. cholerae strains tested, including 2 serotypes and 2 biotypes, were able to elicit a massive and usually fatal cholera-like diarrhea. The virulence depended strongly on the culturing conditions. One strain, C5, caused fatal diarrhea in a dose of about 1000 organisms, even if the temporary ligation was omitted (DIC model). Other modifications were the DIS and the DI model in which the permanent ligature of the cecum or both ligatures were omitted. Duodenal inoculation of organisms in a dose of 100 X the minimum infective dose (MID) in the DIS or DI model did not cause any disease symptom. However, such inoculations were found to cause protection against subsequent challenges with 100 X MID of homologous and heterologous organisms up to 52 weeks after duodenal inoculation. Subcutaneous injection with classical, whole cell cholera vaccine gave only partial protection of short duration. This model might contribute to the understanding of the pathogenesis of cholera as well as to the improvement of efficacy testing of cholera vaccines.
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PMID:Vibrio cholerae infection and acquired immunity in an adult rabbit model. 400 31

The content of D-dimer was studied in 130 patients with cancer at various sites. Twenty-five patients were diagnosed as having pulmonary thromboembolism (PTE), 30 had venous thromboses, and 35 patients had acute and subacute disseminated intravascular coagulation (DIC) syndrome. A control group included 40 patients without thrombotic complications. The studies were performed on an automatic STA COMPACT analyzing device. It has been shown that there is a drastic (10-15-fold) increase in the content of D-dimer as compared with the controls. The highest level of D-Dimer was observed in patients with acute DIC who have significant clinical symptomss. The level of D-dimer was to a lesser extent increased in patients with multiple organ deficiency. The content of D-dimer decreased during therapy anticoagulant therapy. When PTE, venous thrombosis, or DIS are suspected, it is advisable to include the study of D-dimer into a coagulogram.
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PMID:[The clinical value of D-dimer in the diagnosis and treatment of thromboembolic complications and DIC syndrome in cancer patients]. 1631 55

A 41-year-old male, with no previous medical history, was admitted to our intensive care unit with severe isolated neurotrauma and a Glasgow Coma Scale of E1-M1-V1, mid-dilated unreactive pupils and severe abnormalities on the brain CT-scan. A severe syndrome of disseminated intravascular coagulation (DIC) and non-oliguric renal insufficiency developed. Following clinical and neurophysiological examination the patient was declared brain-dead, and the family gave permission for organ donation. The left kidney was transplanted and functioned well immediately. However, in view of the DIC and renal function disorders the right kidney was not considered usable for transplantation elsewhere. Pathological examination revealed many fibrin thrombi in the glomerular capillaries and acute tubular necrosis. This case supports the view that thrombotic microangiopathy in kidneys of patients with DIS, even with renal function impairment, is not an a priori reason for excluding donation.
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PMID:[Kidney donor with severe disseminated intravascular coagulation: transplantation however successful]. 1985 87