Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infection occurring in patients suffering from severe trauma or burns often leads to hypotension, disseminated intravascular coagulation, multiorgan failure, and death. These latter pathophysiologic changes often are associated with Gram-negative sepsis and endotoxemia. Substantial progress has been made in understanding the effector mechanisms for endotoxin (LPS) action with the recognition of the importance of LPS-inducible products of cells of monocytic lineage in mediating LPS-induced injury. Here we will review recent evidence that supports a model for monocyte/macrophage activation by LPS that involves a plasma protein known as lipopolysaccharide binding protein (LBP) and the monocyte differentiation antigen, CD14.
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PMID:A new model of macrophage stimulation by bacterial lipopolysaccharide. 225 81

A prospective controlled study was conducted in 30 patients with lower extremity atherosclerotic gangrene. Their mean age was 66.1 +/- 9.0 years. Examinations were made before and after high leg amputation. The investigators analyzed the following markers of a systemic inflammatory reaction (SIR): IL-1beta, 6, 8, 10, TNF-alpha, and L-2r. The concentrations of myoglobin (a marker of tissue damage), cortisol and blood glucose (markers of sympathoadrenal system activation), D-dimers (a marker of disseminated intravascular coagulation), C-reactive protein (CRP), lipopolysaccharide-binding protein, and fibrinogen were also measured. The signs of muscle damage (such as elevated myoglobin concentrations), stress, and CRP were detected in patients with atherosclerotic gangrene in the pre- and postoperative periods. The risk of pyoinflammatory complications in the immediate postoperative period may be predicted from the higher levels of acute-phase proteins (CRP), proinflammatory cytokines (IL-6), and myoglobin.
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PMID:[Early postoperative systemic inflammatory response in patients with lower extremity atherosclerotic gangrene]. 1865 69