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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is a case report of a 76-year-old women with hematometra due to cervical cancer followed by DIC. To the authors' knowledge this is the first report of such case.
Ginekol Pol 2001 Dec
PMID:[Hematometra in 76-year-old woman followed by DIC and the result of the carcinoma of cervix--a case report]. 1188 9

Retroperitoneal fibrosis (Ormond's disease) is rare chronic inflammatory process, that can occur at any age. It is characterised by development of periaortic fibrous mass leading to progressive obstruction of vessels around the abdominal aorta and ureters. In the one third of cases we can find the causes of disease. There are ergotamine abuse, radiation, retroperitoneal surgery or hemorrhage, urine extravasation and response to different cancers. The other cases are idiopathic disease. We report a case of prostate cancer with unique course. The first manifestations of disease were diffuse peritoneal fibrosis and ureteral obstruction leading to bilateral hydronephrosis. Clinical course and histopathology showed idiopathic Ormond's fibrosis. Patient received oral immunosuppressive treatment (prednisolone 1 mg/kg/day + azathioprine 1 mg/kg/day), followed by intravenous methylprednisolone puls (2 g). Treatment also consisted of DJ-stent placement on the left side. On the right side we were unable to overcome the obstruction of ureter. Because of persistent renal failure, thrombocytopenia, DIC and progressive lower back pain we did control MR and CT scan. The CT scans showed multiple osteolytic bone metastases in vertebral column (the sizes of them were between a few millimetres and 1.5 centimetre). Patient died due to renal failure and haemorrhagic diathesis in the course of disseminated cancer of unknown origin. The postmortem examination revealed diffuse peritoneal infiltration surrounding the ureters, intramural ventricular metastases, pulmonary metastases and vertebral metastases. The prostate was only slightly enlarged. Histological and immunohistochemical examinations of prostate showed primary low-differentiated prostate carcinoma (CK/+/, PAP/+/, PSA/+/). Peritoneal, ventricular and bone infiltrations also were metastases from low-differentiated carcinoma of prostate origin (CK/+/, PAP/+/, PSA/-/).
Pol Arch Med Wewn 2001 Jul
PMID:[Ormond's fibrosis, bone osteolysis and stomach intramural metastases in the course f low-differentiated prostatic cancer]. 1192 71

The objective of this paper was the description of a case of 68-year old male patient with epithelioid gastrointestinal stromal tumor (GIST). Disseminated intravascular coagulation syndrome (DIC) as the first and predominant revealed symptom of disease was observed. The final diagnosis was performed using the specific immunohistochemic and ultrastructural assays. The diagnostic and therapeutic difficulties were presented in discussion.
Pol Arch Med Wewn 2001 Oct
PMID:[Recurrent disseminated intravascular coagulation in the course of gastrointestinal stromal tumor (GIST)]. 1199 14

A case of a 47-year-old man, a Jehovah's Witness, with left atrial myxoma is presented. Clinical presentation included several months of thrombocytopenia and disseminated intravascular coagulation. Deterioration of heart failure was complicated by pneumonia and worsening of disseminated intravascular coagulation. Therapeutic challenges related to patient's religious beliefs are discussed.
Kardiol Pol 2003 Nov
PMID:[Thrombocytopenia and disseminated intravascular coagulation in a patient with left atrial myxoma--a case report]. 1466 94

The aim of report is to present the possibilities of applying NovoSeven in serious coagulopathy in course of various obstetrical complications. At present it is utilised in acquired coagulopathy, bleedings, traumatic cases and extensive surgical operations especially associated with DIC. We report two cases of severe complications during delivery. Both patients had a massive bleeding, severe disorders of haemostasis, which on effect were leading to DIC. In therapy a large quantity of blood products were applied. Conventional treatment with anticoagulant did not give any results. Administration of NovoSeven gave at last radical turn in course of treatment and the improvement in patient's state. In obstetrical practice NovoSeven is recommendable supplement of conventional treatment in severe coagulopathy.
Ginekol Pol 2003 Oct
PMID:[Effectiveness of recombinant activated factor VIIA (NovoSeven) in case of severe obstetric complication with coagulopathy]. 1466 94

The aim of this work was to assess the prevalence of the blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation (DIC) in acute-poisoned patients. The number of examined people was 231, including 140 acute-poisoned patients (of whom 83 showed DIC's finding) and 91 clinically healthy controls. The resistance of examined plasma to the anticoagulating properties of activated protein C was assessed by Chromogenix APC-Resistance V assay (APC-R-V). Abnormal results of APC-R-V were found to be 6-fold more frequent in acute-poisoned patients with DIC syndrome: 20 of 83 (24.1%), vs 3 of 91 (3.3%) for the control. The differences were statistically significant at p=0.0001 Mean values of coefficient R were statistically significantly lower in the acute-poisoned patients with DIC syndrome than the control, p<0.001. Genetic tests preformed in 37 patients confirmed V Leiden mutation to be present people whose R index value was below 2.0. Detection of APC-R in acute-poisoned patients could facilitate implementation of suitable preventive procedure before the DIC symptoms become manifest.
Pol Merkur Lekarski 2004 Oct
PMID:[Blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation in acute-poisoned patients]. 1569 Jul 1

More often we are faced with the cases of young people (who are in a serious condition) who land in ICU, because of severe narcotics intoxication, which they took occasionally on the concerts, discotheques and social events. From 1997 we observed rapid increase of admission to hospitals due to amphetamine, MDMA (2,3-methylenedeoxymethamphetamine which is a main component of a tablet called ecstasy) and THC (9-d tetrahydrocannabinols which are a component of sunn hemps) intoxication and decrease of opioid's poisoning. 23 years old patient was admitted to ICU in critical condition after severe narcotics intoxication. Patient was deeply unconscious (GCS 3) with tetraplegia and high temperature (39.6 degrees C). He had endotracheal tube (artificially ventilated) and hypovolemic shock with circulatory insufficiency (blood pressure was supported by 3 catecholamines). We observed many petechias and ecchymoses which suggested vascular haemorrhagic diathesis. It was found that the patient had disseminated intravascular coagulation and rhabdomyolysis with acute renal failure which was treated by dialysis. After 26 days of intensive treatment the patient was conscious, he had also efficient circulatory and respiratory system but with slight improvement of neurological state. In this condition he was admitted on nephrology ward to continue the treatment and start rehabilitation. The presence of high concentration of amphetamine, MDMA and THC in blood, extreme dehydration and electrolytes disturbances caused rhabdomyolysis, DIC syndrome and acute renal failure which make the prognosis worse and complicate the treatment. Estimating probability of death of this patient in SAPS II scale (Simplified Acute Physiology Scale) he has bad prognosis (86 points gives 95% of death probability). The patient is alive (what is a big success), probably thanks to quick arrival to specialized medical centre and dialysis treatment which was started early.
Pol Merkur Lekarski 2005 Apr
PMID:[Rhabdomyolysis, disseminated intravascular coagulation and acute renal failure after severe narcotics intoxication (MDMA, THC, amphetamine)]. 1616 30

Ischaemic stroke in thromboembolic mechanism may be a first sign of neoplastic disease, as in the presented case of a 56-year-old woman. Progressive trombocytopenia, anaemia with reticulocytosis and schistocytes in peripheral blood smear, elevated serum LDH activity as well as coexisting myocardial infarction initially suggested Moschcowitz syndrome. However, plasma exchange did not improve her neurological status and D-dimer values increase in subsequent evaluations indicated chronic DIC. At the same time, on transesophageal echocardiography, thrombotic endocarditis was diagnosed. Screening for cancer showed high CA 125 marker and chest computed tomography revealed lung tumor, not visible on earlier chest X-ray. In further treatment she underwent palliative radiotherapy and continued low molecular weight heparin. The neoplastic process had an unfavorable course and she died after four months. The authors point out that in case of multifocal ischaemic stroke and coexistent thrombocytopenia, neoplastic hypercoagulable state and thrombotic endocarditis should be considered.
Neurol Neurochir Pol
PMID:[Multifocal ischaemic stroke and myocardial infarction in a woman with occult lung cancer complicated with chronic DIC and thrombotic endocarditis]. 1719 80

Peripartum cardiomyopathy (PC) and preeclampsia with HELLP syndrome are serious complications of pregnancy, but the coincidence of both in one pregnancy is extremely rare. Here, we report a case of 32-year-old primipara who in 35th Hbd presented for the first time in her life symptoms of severe heart failure (HF) in NYHA class III/IV. In 37th Hbd the diagnosis of PC was established based on clinical status and echocardiographic examination, which demonstrated a dilatation of heart chambers and impaired left ventricular systolic function with decreased ejection fraction (EF) 17%. In 37th Hbd she developed symptoms of preeclampsia complicated with HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and further a DIC syndrome as well. Because the patient was in critical condition and the foetus' life was threatened the pregnancy was terminated with urgent cesarean section. Then the patient developed shock, respiratory insufficiency and increasing renal failure. Successful treatment, included administration of pressor amines, respirator, hemodialyses, multiple fresh frozen plasma and blood transfusions. The symptoms of HELLP syndrome resolved by 9th day of treatment. Although optimal treatment of HF was administered with significant clinical improvement, the normalization of left ventricle systolic function was not observed. At 2 and 13 months follow-up, EF remained low and was 34 and 36% respectively. This allows to diagnose persistent PC. Based on the case, the issues of etiopathogenesis, treatment, prognosis and the risk of recurrence of PC and HELLP syndromes in a possible pregnancy are discussed.
Pol Arch Med Wewn 2006 Oct
PMID:[Peripartum cardiomyopathy and preeclampsia complicated with HELLP syndrome--a case report]. 1841 98

The purpose of this study was to determine changes in coagulation profile parameters in cattle with left abomasal displacement (LAD). The study was performed on 20 Holstein-Friesian (H-F) cows divided into two groups: group I--10 cows with diagnosed left abomasal displacement and group II--10 clinically healthy cows. Coagulation tests, including TT (thrombin time), PT (prothrombin time) and APTT (activated partial thromboplastin time), were conducted, and fibrinogen content, D-dimer content, AT III (antithrombin III) activity and platelet (PLT) count were determined in all the animals. Prolonged TT, PT and APTT, a higher fibrinogen and D-dimer content, a drop in AT III activity and thrombocyte count were observed in the cattle with LAD. The above abnormal coagulation profiles were most predominant in three cows which died after surgical repositioning of the abomasum. The results of the study indicate that in cattle with abomasal displacement, the disseminated intravascular coagulation (DIC) syndrome was the most significant risk factor for mortality.
Pol J Vet Sci 2008
PMID:Changes in the coagulation profile of cattle with left abomasal displacement. 1922 27


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