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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A diagnostic method is described for determining the parameters of the human blood plasma coagulation and fibrinolysis by turbidimetry. Diluted plasma with thrombin and streptokinase is mixed to initiate clot formation and subsequent clot dissolution. The resultant profile of absorbance versus time is analysed to determine six parameters: plasma coagulation time, the rate of coagulation, fibrinogen concentration, the rate of fibrinolysis, fibrin clot half-lysis and lysis time. The assay is precise, sensitive and requires 0.1 ml plasma. The method has a good correlation with generally accepted haemostatic tests and allowed us to recognize the stage of DIC syndrome for less than 10 minutes. This new approach was successfully applied for studying the haemostasis in patients with acute intestinal infection.
Mater Med Pol
PMID:Simultaneous determination of coagulation and fibrinolysis parameters for diagnostics of disseminated intravascular blood coagulation (DIC). 130 73

Two cases of the acute disseminated intravascular coagulation (DIC) are presented. DIC in the first case was diagnosed in healthy pregnant woman without any obstetric pathology. This patient recovered completely. The acute DIC in another patient preceded the acute promyelocytic leukemia. The patient died despite a control of DIC. DIC therapy included antifibrinolytic agents and additionally corticoids in pregnant patient. Heparin was not administered because of post partum period and foreseen cytostatic therapy in the leukemic patient.
Pol Tyg Lek
PMID:[2 cases of acute disseminated intravascular coagulation in normal pregnancy and as the first symptom of acute promyelocytic leukemia]. 223 4

The authors observed 53 cases of diabetic ketoacidosis treated with low doses of insulin. Mean age of the patients was 41 +/- 17 years, duration of diabetes mellitus 7.5 +/- 6.4 years. Ketoacidosis was due to: infections in 36%, other diseases in 7%, and cessation of insulin therapy in 25% of cases. Ketoacidosis was a first sign of diabetes mellitus in 19% of cases while causative factor was not detected in 13% of cases. At the admission to hospital mean blood pH was 7.02 +/- 0.15, mean bicarbonate concentration 6.17 +/- 3.45 mM/l, and glycaemia 40.6 +/- 16.8 mM/l. Therapy of ketoacidosis was complicated by hypopotassemia in 1 patient and transient hypoglycaemia in another patient. Five patients (9.6%) died. Infections, myocardial infarction, acute pancreatitis, pulmonary edema, and disseminated intravascular coagulation were the causes of deaths.
Pol Tyg Lek
PMID:[Analysis of the cause of death in diabetic ketoacidosis based on 5 years of personal observation]. 251 62

Human fibrinopeptides A and B (FAB) increased the arterial blood pressure, accelerated the heart rate and elevated permeability of capillaries, produced a vasodilatory effect, evoked positive chronotropic and inotropic action on the isolated heart and did not affect the coronary flow. They lowered the content of glycogen in the heart muscle. They did not affect the concentration of glucose and elevated the content of lactic acid and free fatty acids (FFA) in the blood. As FAB are present in large quantities in the blood during disseminated intravascular coagulation, they may play an essential role in pathology of the circulatory system of mammals.
Pol J Pharmacol Pharm
PMID:Some pharmacological and biochemical effects of fibrinopeptides A and B in the circulatory system of rats. 666 38

The reactivity of the central nervous system in the disseminated intravascular coagulation was studied. In this state the action of pentylenetetrazol and thiopental were decreased. Also shortening of tonic phase of electric convulsions was observed. No changes were noted in the contents of noradrenaline and serotonin, whereas slight increase in dopamine level in some regions of brain was found. It seems that observed effects are connected with other mechanisms than interaction with central mediators.
Pol J Pharmacol Pharm 1982
PMID:Reactivity of the central nervous system in the disseminated intravascular coagulation in rats. 716 13

Important discoveries of the last twenty years indicate that blood platelets play an important role in the etiopathogenesis of many serious diseases. These include atherosclerosis with its acute vascular complications like myocardial infarction and many forms of disseminated intravascular coagulation. Their role is not limited here to platelet participation in thrombus formation. This is why we are constantly searching for a method which will allow to detect platelet activation in vivo before any important damage to vital organs and tissues will take place. Despite the implementation of sophisticated modern laboratory techniques reliable assessment of such activation poses still a clinical and laboratory problem.
Acta Haematol Pol 1994
PMID:[Laboratory methods of estimating blood platelet activation]. 799 72

A case of the female patient with gastric carcinoma with metastases into lymph nodes and vertebrae is presented. Generalized DIC with subarachnoid haemorrhage confirmed by CSF examination has occurred in the course of the disease. Applied treatment failed.
Pol Tyg Lek
PMID:[Neurologic complications of disseminated intravascular coagulation in a patient with a stomach neoplasm]. 800 52

Symptoms of endogenic hepatic coma were observed in the course of acute hepatitis in 17 patients admitted to the I Clinic of Infectious Diseases of Silesian Medical School between 1987 and 1992. Five of them were treated with the arterialization of portal blood. At least one exchange transfusion preceded the arterialization in four cases. Recovery was obtained in 3 patients. Two patients died because of complications which occurred during the twenty-four hours after the intervention. In the first case the reason of the death was the extensive myocardial infarction, in the second one-DIC and ARDS. As it has been observed, the prothrombin rate should not be lower than 30% in these patients who are to undergo the arterialization of portal blood. This value of the prothrombin rate is provided by at least one exchange transfusion.
Pol Tyg Lek
PMID:[Endogenic hepatic coma in the course of acute hepatitis treated with arterialization of portal blood]. 823 45

We report on a 3-day-old newborn with critical coarctation of the aorta, coexisting adrenal and intracranial hemorrhages and acute renal failure requiring dialysis. Severe hypoglycemia, hyperbilirubinemia, mounting anemia and thrombocytopenia, clotting disturbances suggesting DIC, pneumonia, hypertension, increasing circulatory failure and repeated intracranial hemorrhage were observed and were the reason for postponing heart surgery. The child was operated on during the third week of hospitalisation on an emergency basis. The cardiac surgery procedure was performed successfully.
Pediatr Pol 1995 Dec
PMID:[Diagnostic and therapeutic problems in a newborn with aortic coarctation, adrenal and intracranial hemorrhages and renal failure]. 864 47

We reported on a 74 year old patients with local advanced prostatic carcinoma. Following prostatic surgery an increased bleeding tendency was observed. The patients showed clinical and laboratory evidence for consumption coagulopathy with hyperfibrinolysis. The laboratory data were: marked decrease of AT III, Protein C, increase of thrombin/AT III complex level, fibrin degradation products (FDP) and antigen of t-PA. The treatment was ended successful.
Pol Tyg Lek 1996 Feb
PMID:[Disseminated intravascular coagulation syndrome with secondary fibrinolysis activation in prostatic carcinoma]. 875 45


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