Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma TNF-a and IL-6 levels of endotoxin-induced DIC in rabbits were measured by ELISA methods. Simultaneously, the effects of Reduqing (RDQ) on TNF-alpha and IL-6 were also studied. The results showed that TNF-alpha and IL-6 levels increased markedly in model group, which were confirmed with obvious damage of tissue or organ. Co-administration of RDQ could reduce plasma TNF-alpha and IL-6 levels, together with mild tissue or organ damage. These results indicated TNF-alpha and IL-6 might be involved in pathogenesis of endotoxin-induced DIC, RDQ might be used in preventing or treating DIC through mechanism of reducing TNF-alpha and IL-6 levels.
 ...
PMID:[Effects of reducing injection on plasma TNF-alpha and IL-6 levels in rabbits with endotoxin-induced DIC]. 754 88