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Disease
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Enzyme
Compound
Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0012739 (
disseminated intravascular coagulation
)
8,673
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Male rats of 260 g were exposed to hyperbaric conditions of oxygen with different partial pressures and the changes of the haemostasis were studied. In 100% oxygen at 2
ATA
, the animals died within 48 h. In 100% oxygen at 1
ATA
, death occurred only after 3 d; however, in 24-48 h there developed
disseminated intravascular coagulation
(
DIC
). At the same time uncompensated acidosis of 7.34 +/- 0.02 was measured. Perivascular bleeding could be histologically demonstrated in different organs. The mixture of 60% oxygen and 40% nitrogen caused only a minimal
DIC
while a mixture of 40% oxygen and 60% nitrogen caused no changes in the haemostasis. Volunteer young males exposed to the mixture of 60% oxygen and 40% nitrogen, developed the beginning symptoms of
DIC
, which made it necessary to stop the experiments.
...
PMID:Disseminated intravascular coagulation developed in hyperbaric oxygen. 65 96
