Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coagulation profiles of serum fibrinogen, factors V and VIII and haemoglobin in normal pregnancies during labour, delivery and the early puerperium are presented. These factors were also studied in patients with abruptio placentae, in intra-uterine death, and in patients whose pregnancies were terminated with intra-amniotic saline and prostaglandin F2alpha. An assessment of fibrinolytic activity in these patients was made using qualitative (euglobulin lysis time) and quantitative (FR-antigen) tests. The coagulation findings presented form a basis for the rational management of defibrination in obstetrics.
 ...
PMID:Defibrination in obstetrics. Modern concepts. 80 77

A comparative histologic study of plancentas aborted after infusion of hypertonic saline or prostaglandin F2alpha into the amniotic cavity toinduce abortion is presented. Five placentas from spontaneous abortions served as controls. Saline abortion produced edema of the membranes; congested,dilated, thrombotic blood vessels; and subchorionic necrosis. Prostaglandin did not produce edema, but created marked vasospasm as evidenced by thickened vessels without subchorionic necrosis. The absence of serious sepsis and defibrination in prostaglandin-induced abortions is probably related to the absence of tissue necrosis.
 ...
PMID:A histologic study of the placentas of patients with saline- and prostaglandin-induced abortion. 94 Jun 54

The possible predisposing causes of difibrination in the pregnant woman are discussed. Coagulation profiles and qualitative and quantitative assessment of fibrinolytic activity during labor, delivery and the early puerperium in normal pregnancies are presented. These factors were also studied in patients with abruptio placentae and prolonged intrauterine fetal death and in women whose pregnancies were terminated with intraamniotic infusion of hypertonic saline or prostaglandin F2alpha. The findings suggest that a minor degree of physiologic defibrination develops during normal labor that is qualitatively similar to, but of much lesser magnitude than, the pathologic defibrination syndrome commonly associated with abruptio placentae or prolonged intrauterine fetal death. Some degree of defibrination occurs in women undergoing saline abortion, similar to that of women during normal parturition, but does not usually reach clinically significant levels. The coagulation changes seen during prostaglandin abortion suggest that a minor degree of defibrination occurs that is substantially less than that seen during saline abortion. The findings presented form a basis for the rational management of defibrination in the pregnant woman.
 ...
PMID:Current concepts of defibrination in the pregnant woman. 100 95

In 1989-90 in India, physicians used 4 different methods to induce second trimester abortion (14-20 weeks gestation) in 200 women at the Lokmanya Tilak Municipal General Hospital in Sion in Bombay. In 50 women each, they introduced 200 ml of 20% hypertonic saline into the amniotic sac, after removing 35-200 ml of amniotic fluid; 150 ml of ethacridine lactate extraovularly; prostaglandin F2 intramuscularly at regular intervals; and a cupful of 5% povidone-iodine topical solution in 150 ml of sterile normal saline extraamniotically. Intravenous oxytocin drip was started the morning after induction in all but those women receiving prostaglandin F2 to reduce the induction-abortion interval. 5% povidone-iodine solution successfully induced abortion in 100% of cases. The success rates for ethacridine lactate, hypertonic solution, and prostaglandin F2 were 98, 96 and 90%, respectively. Ethacridine lactate had the highest complete abortion rate (42%) followed closely by 5% povidone-iodine (39%). Prostaglandin F2 resulted in the shortest mean induction-abortion interval (20 hours vs. 38 hours for hypertonic solution, 30 hours for ethacridine lactate, and 32 hours for 5% povidone-iodine solution. 4 (8%) of the 50 women who underwent an abortion induced by hypertonic solution required a blood transfusion. Another woman undergoing hypertonic solution abortion developed disseminated intravascular coagulation and died. The only women who experienced vomiting and loose stools were women receiving prostaglandin F2 (30 women [60%]). The most cost-effective abortion method was 5% povidone-iodine solution in normal saline, indicating that this is the preferred method for poor patients.
 ...
PMID:Comparative study of midtrimester termination of pregnancy using hypertonic saline, ethacridine lactate, prostaglandin analogue and iodine-saline. 146 Mar 14

Extensive coagulation studies have been carried out on patients undergoing second trimester abortions induced by prostaglandin F2alpha. 30 patients with intraamniotic instillation of PGF2alpha have been studied and an additional 10 patients who were aborted by the extraovular route. Blood samples were obtained before onset of medication and at frequent intervals after beginning of drug administration as well as at the time of abortion. Intraamniotic administration of PGF2alpha resulted in increased levels of fibrinogen, platelets, factors 8 and 5, profibrinolysin, and fibrinolytic inhibitors during the 24 hour period after beginning of medication. The rise in the coagulation factors is suggestive of mild inflammatory process not associated with infection. Most of the indices have returned to normal levels shortly after expulsion of the fetus and placenta. Only 1 patient receiving PGF2alpha showed evidence of fibrin monomer formation as determined by protamine sulfate precipitation. Extraovular results were similar. The results have been compared to those obtained in this laboratory following hypertonic saline. With saline the results show a decrease in many factors, indicating disseminated intravascular coagulation. PGF2alpha may provide a safer method of second trimester abortion as far as the coagulation mechanism is concerned than does hypertonic saline.
 ...
PMID:Coagulation studies during second-trimester abortions induced by PGF2alpha. 483 89