Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hemocoagulation was studied in 116 patients with prostatic adenoma, stage II, before and 1, 4-7, 8-10 and 11-15 days after surgical intervention. Out of 77 patients exposed to routine adenomectomy, 55 persons were treated 12-14 days prior the surgery with therapeutic dosages of a vitamin A, E, C, P complex. After the operation they were given nicotinic acid in presence of the double load of vitamins A and E. Out of 39 persons exposed to urgent adenomectomy 19 patients were administered the double dosages of the same vitamins before the operation. The rest of the both groups were postsurgically given acetylsalicylic acid instead of vitamins. It was stated that the aforementioned vitamin therapy significantly decreased postsurgical blood coagulation disorders (in those who were prepared for the operation beforehand it happened before adenomectomy), improved the clinical course and outcomes of the postsurgical period. Presurgical investigations reveal an accelerated intravascular coagulation and mild manifestations of the DIC syndrome in patients with prostatic adenoma. After the operation the syndrome manifestations increase but rarely develop into stages II and III that are usually accompanied by consumption coagulopathy. To follow the syndrome progression one could use only 5 out of 13 tests defined by the authors: activated time of recalcification, prothrombin index, fibrinolytic activity, products of fibrin degradation and an ethanol test.
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PMID:[Shifts in the blood coagulation during adenomectomy of the prostate]. 169 31

1. In case of severe surgical infections in childhood the haemostatic system may be involved combined with aggregation of thrombocytes and disseminated intravascular coagulation. 2. The possible changes of haemostatic system are discussed. 3. The effect of therapeutical correction using heparin, gamma-tocopherol, nicotinic acid, fitin, kurantil and fresh plasma on the haemostatic system values have been analyzed.
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PMID:[Correction of the hemostasis system in severe surgical infections in childhood]. 194 61

Status of hemostasis system and occurrence of postoperative thromboembolic complications were assessed in 246 lung cancer patients in whom combined treatment included artificial hyperglycemia. The latter condition contributed to higher blood coagulability resulting in lung artery thromboembolism in some cases. Administration of a combination of heparin, curantil and nicotinic acid was followed by a decrease in blood coagulability, increase in anticoagulation function, decrease in platelet aggregability, activation of fibrinolysis and regression of biochemical signs of DIC syndrome thereby assuring a drop in the occurrence of thromboembolic complications.
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PMID:[The prevention of the hypercoagulation syndrome during the combined treatment of lung cancer patients using artificial hyperglycemia]. 203 27

Therapeutic management of 42 parturients with the syndrome of obstetric coagulopathy who had suffered hemorrhagic shock in labor or early postpartum period was analysed. The signs of consumption coagulopathy were revealed in all the examinees. A decrease in the blood fibrinolytic activity observed in the presence of hypocirculation led to a microcirculatory crisis and the development of polyorganic failure. Agents of fibrinolytic activation and disaggregation from the nicotinic acid group or its derivatives, which were given in the postresuscitation period potentiated the therapeutic efficacy and therefore decreased lethality rates.
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PMID:[Diagnosis and intensive therapy of obstetric coagulopathic syndrome in parturients in the early post-resuscitation period]. 281 82

The effect of i. v. administered nicotinic acid was examined in 23 patients. Before the patients had undergone an AFB-operation. 11 cardiovascular parameters were quantitatively examined, calculated and statistically controlled. The authors observed a short but clear decrease of pressure and resistance in the arterial system after the injections of nicotinic acid. The aim of increasing the blood supply to poststenotic regions can however not be attained in this way. The decrease can rather lead to a lack of the blood supply of these regions. The authors could verify that the vascular effect of nicotinic acid is not caused by adrenergic blockade. We are of the same opinion as other authors who maintain that nicotinic acid could be used in the therapy of the "shock lung". It is said that nicotinic acid as a fibrinolytic substance might counteract the Disseminated Intravascular Coagulation and that it could counteract the danger of oedema in the pulmonary system by decreasing pressure and resistance for a short time.
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PMID:[Cardiovascular changes caused by nicotinic acid (author's transl)]. 739 99