Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0012739 (
disseminated intravascular coagulation
)
8,673
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Dictamnine
(4-methoxyfuro[2,3-b]quinolone,
DIC
), a common furoquinoline alkaloid in the family of Rutaceae, showed diverse biological activities. To investigate the
in vivo
metabolic pathways of
DIC
, metabolism of
DIC
in mice was studied using a high-performance liquid chromatography coupled to electrospray ionization of hybrid linear trap quadrupole orbitrap (HPLC-LTQ-Orbitrap) mass spectrometer. Nine metabolites were identified in the
DIC
-treated mouse urine, plasma, and fecal samples, of which two were identified as new metabolites. The major metabolic pathways of
DIC
in animal and human liver microsomes were confirmed in the present study, including o-demethylation, monohydroxylation,
N
-oxidation, and 2,3-olefinic epoxidation pathways. For the first time, a mono-acetylcysteine conjugate of
DIC
(M9) was detected from
DIC
-treated mouse urine and plasma samples, and 4-methoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (M10) and 2-(2,8-dihydroxy-4-methoxyquinolin-3-yl)acetaldehyde (M11) were identified as new metabolites of
DIC
; furthermore, using an
in vitro
human fecal incubation model, furo[2,3-b]quinolin-4-ol (M1) was verified to be a microbial demethylated metabolite of
DIC
. Collectively, the present study provided new information on the
in vivo
metabolic fate of
DIC
.
...
PMID:Identification of
In Vivo
Metabolites of Dictamnine in Mice Using HPLC-LTQ-Orbitrap Mass Spectrometry. 3106 42
