Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pregnancy termination by the intraamniotic injection of hypertonic saline may result in coagulation defects. This complication seems to be uncommon with prostaglandins. The present study was designed to elucidate any possible effects of prostaglandin administration on coagulation parameters in patients with fetal death in utero. Labour was induced in 20 cases of intrauterine fetal death by either intravenous (11) or intramuscular (9) administration of Sulprostone. Normotest, thrombin clotting time, ethanol fractionation, fibrinogen level and platelet count were obtained in each patient prior to and immediately after drug administration. Although retention of the fetus for as long as 84 days was recorded (mean 14 days), no patient presented with abnormal clotting parameters. Prostaglandin induction was successful in all 20 cases. After explosion of the fetus, coagulation parameters were not significantly different from pretreatment values. Estimated blood loss never exceeded 500 cc. It is concluded that intramuscular or intravenous administration of Sulprostone for induction of labour in fetal death in utero does not affect the clotting system nor trigger off disseminated intravascular coagulation.
 ...
PMID:[Blood coagulation parameters in prostaglandin-induced labour after intrauterine fetal death (author's transl)]. 67 15

A comparative histologic study of plancentas aborted after infusion of hypertonic saline or prostaglandin F2alpha into the amniotic cavity toinduce abortion is presented. Five placentas from spontaneous abortions served as controls. Saline abortion produced edema of the membranes; congested,dilated, thrombotic blood vessels; and subchorionic necrosis. Prostaglandin did not produce edema, but created marked vasospasm as evidenced by thickened vessels without subchorionic necrosis. The absence of serious sepsis and defibrination in prostaglandin-induced abortions is probably related to the absence of tissue necrosis.
 ...
PMID:A histologic study of the placentas of patients with saline- and prostaglandin-induced abortion. 94 Jun 54

The origin of pre-eclampsia lies in uteroplacental ischemia due to an anomaly of the "vascular insertion" of the placenta. Although the cause of this anomaly remains unknown, it would appear to include both a genetic and an immunological origin possibly favourised by special underlying conditions and certain obstetric circumstances. Prostaglandin imbalance (in particular prostacyclins and Thromboxane A2) appears to be one of the chief factors governing these anomalies. One of the consequences of these mechanisms is the onset of hypertension but other disturbances are essential features. In particular, disseminated intravascular coagulation may occur leading to the release of numerous microthrombi which cause placental (leading to chronic fetal distress), renal, hepatic and cerebral lesions.
 ...
PMID:[Physiopathological elements of pre-eclampsia and the role of the main complementary tests]. 176 67