Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There appears to be no clinically significant difference in blood loss or transfusion requirements after transurethral resection of the prostate (TURP) when intravesical 0.5% aminocaproic acid is compared with 0.9% sodium chloride irrigation in patients during the first three days after surgery. This is probably because early post-TURP bleeding is due to inadequate hemostasis or perforation of the prostatic capsule, and not excessive local or systemic fibrinolysis. However, we suggest that intravesical aminocaproic acid might be a useful alternative to systemic antifibrinolytic therapy in patients with delayed, recurrent, excessive post-prostatectomy bleeding, which is thought to be due to fibrinolysis. Since aminocaproic acid is not systemically absorbed after bladder instillation, intravesical administration causes few side effects and does not necessitate screening patients for disseminated intravascular coagulation prior to treatment.
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PMID:Safety and efficacy of intravesical aminocaproic acid for bleeding after transurethral resection of prostate. 351 25

Between January 1990 and December 1991, physicians used either intra-amniotic 20% hypertonic saline (HSI) solution (no more than 200 ml) or 3 mg intracervical prostaglandin E2 gel (PGE2) to induce mid-trimester abortion in 149 women at Ramathibodi Hospital in Bangkok, Thailand. 125 women were in the HSI group and 24 were in the PGE2 group. The mean induction to abortion time was 28.4 hours for the PGE2 group and 31.7 hours for the HSI group. The longest induction to abortion time was 73 hours for the HSI group and 127.2 hours for the PGE2 group. Nausea and vomiting only occurred in women in the PGE2 group (16.7%). Only 4 (3.3%) HSI cases developed fever. One of these cases had disseminated intravascular coagulation (DIC) defect which was likely caused by contamination during instillation of HSI. This case lost more than 500 ml of blood. One HSI case experienced increased electrolytes during HSI instillation, which was likely caused by leakage of sodium chloride into the vascular system. Even though many HSI cases (63.3%) experienced a retained placenta, hemorrhaging occurred in only 1 (0.8%) HSI case, the one with DIC. The women in the PGE2 group were less likely to experience a retained placenta (25%). The average length of stay in 70% of cases in both groups was 2 days. Provided clinicians use aseptic techniques and closely observe HSI patients, HSI termination of midtrimester pregnancy is effective and safe. HSI is less expensive than PGE2 and is available in most developing countries. PGE2 can be used as an alternative method instead of hysterotomy.
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PMID:Mid-trimester abortion using hypertonic saline or prostaglandin E2 gel: an analysis of efficacy and complications. 779 49

On December 23, 2014, the New York State Department of Health (NYSDOH) was notified of adverse health events in two patients who had been inadvertently administered nonsterile, simulation 0.9% sodium chloride intravenous (IV) fluids at an urgent care facility. Simulation saline is a nonsterile product not meant for human or animal use; it is intended for use by medical trainees practicing IV administration of saline on mannequins or other training devices. Both patients experienced a febrile illness during product administration and were hospitalized; one patient developed sepsis and disseminated intravascular coagulation. Neither patient died. Staff members at the clinic reported having ordered the product through their normal medical supply distributor and not recognizing during administration that it was not intended for human use.
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PMID:Notes from the field: Adverse events associated with administration of simulation intravenous fluids to patients--United States, 2014. 2574 84