Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cardiac haemangiomas are exceptionally rare benign vascular tumours. We report a case of cardiac haemangioma presenting with pyrexia of unknown origin and clinical features simulating sepsis with disseminated intravascular coagulation. The clinical course was complicated by systemic embolism.
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PMID:Necrotic cardiac haemangioma masquerading as sepsis with disseminated intravascular coagulation. 1608 50

A 49-year-old woman was admitted to our hospital because of fever of unknown origin. The patient had long-lasting spiking fever, hepatosplenomegaly, pleural effusion, and skin rash. Laboratory tests showed marked leukocytosis and an extremely high serum ferritin level (240 000 ng/ml) accompanied by disseminated intravascular coagulation and hemophagocytic syndrome. Most of the patient's features were compatible with a diagnosis of adult-onset Still's disease (AOSD), the rash, however, was not a typical rheumatoid rash but multiforme erythema. Biopsy of a breast nodule revealed breast cancer, leading us to a diagnosis of paraneoplastic syndrome mimicking AOSD. Although this is a rare disorder, cases resembling the present one have been reported, indicating the importance of including paraneoplastic syndrome in the differential diagnosis of AOSD.
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PMID:A case of paraneoplastic syndrome mimicking adult-onset Still's disease. 1714 3

Myxomas, as other primary cardiac tumors, appear rarely. The most common symptoms are typical of mitral stenosis or peripheral embolism. The rarity of infected cardiac myxomas leads to numerous diagnostic and therapeutic difficulties. We present a case of a 67-year-old man with fever of unknown origin. Laboratory results disclosed signs of sepsis, disseminated intravascular coagulation, acute renal failure, and neuroinfection. Blood cultures were positive for methicillin-resistant Staphylococcus aureus. Transthoracic echocardiogram revealed enlarged left atrium filled with tumor with mobile structure protruding into the left ventricle during diastole. Abnormal intra-atrial mass were also apparent in chest computed tomography (CT). Because of sepsis complicated by coagulation disorders, surgical treatment was postponed. On the 11th day, a large retroperitoneal hematoma occurred, and it was punctured under ultrasonography (USG) control. After 37 days of intensive medical therapy, a stable patient was operated. A giant tumor fixed to the atrial wall between the pulmonary veins' orifices was excised and confirmed as myxoma in histological tests. The patient was discharged in good condition and was followed up for several months with no further complications.
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PMID:Sepsis complicating giant cardiac myxoma. 1835 81

A 78-year-old woman was admitted to our hospital with lumbago. Her activities of daily living had previously been completely independent. However, she developed temporary chills in January 2009, that improved without treatment, but recurred on February 7, 2009 in association with left lumbago and loss of appetite. She was then referred to our hospital with a disturbance of consciousness and high fever on February 14. A blood test performed on admission revealed an elevated inflammatory response, coagulation disorder and low platelet count, and abdominal computed tomography demonstrated findings suggestive of pyogenic spondylitis. The patient was therefore admitted and treated with antibiotic therapy; however, she died on day 8 due to complications of disseminated intravascular coagulation. An autopsy showed isolated pulmonary valve endocarditis. The patient's history was later found to include regular dental treatment, and the same Streptococcus group G was detected in cultures of the sputum, blood and vegetation. It is important to interview patients regarding their history of dental treatment, particularly elderly individuals with fever of unknown origin.
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PMID:[A case of isolated pulmonary valve infective endocarditis in a 78-year-old woman]. 2549 75


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