Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HELLP-syndrome is one of the most severe variants of liver failure in pregnancy. The incidence among pregnant patients is 0.5-0.9%, and in presence of severe preeclampsia and eclampsy the incidence is 10-20%. Pathogenesis of HELLP-syndrome has common features with pathogenesis of preeclampsia, DIC-syndrome and fatty hepatosis of pregnant, this is confirmed by pathomorphological changes of liver in women with HELLP-syndrome. Efficacy of conservative therapy (corticosteroids, magnesium sulphate, hypotensive therapy, hepatoprotectors) and disintoxication methods (plasmapheresis, MARS-therapy) is not evident. Difficulties of timely diagnosing, symptomatic nature of treatment, severity of complications lead to high rates of maternal (up to 25%) and perinatal (up to 34%) mortality. The only radical and efficient method of HELLP-syndrome treatment available is a timely delivery. That's why the revelation and consideration of the slightest clinical and laboratorial manifestations is very important in pregnancy.
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PMID:[Clinicopathologic characteristics of HELLP-syndrome]. 2140 Aug 2