Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study shows a close relationship between incidence of ovine babesiosis caused by Babesia ovis and the activity period and distribution area of the vector tick Rhipicephalus bursa. The most important factor limiting the distribution of this tick is a decrease in humidity. In general, it is absent from areas with an average annual rainfall of less than about 300 mm. The rate of parasitaemia and the degree of anaemia were not correlated. Decrease of the packed-cell volume ranged from 30 to 40%. Parasitized erythrocytes were not observed to block capillaries in the brain, which explained the absence of nervous symptoms in acute babesiosis. The kidney was the most severely affected organ, exhibiting acute glomerulonephritis. The lesions observed were suggestive of vascular alteration and vascular stasis, leading to anoxia of the tissues. A disseminated intravascular coagulation (DIC) syndrome was recorded in sheep infected with babesiosis. Biochemical studies revealed possible damage to the liver and kidneys. Most of the lambs (85%) that were infested with larvae, and all lambs infested with adult R. bursa ticks reacted serologically to B. ovis antigen. The serological reactions following infestation with the larvae occurred much later than those following infestation with the adult stage. Both transovarial and transstadial transmission of the parasite were demonstrated. A study of antibodies to B. ovis using IFAT in hoggets and ewes revealed high serological prevalence, i.e., 88.9% in ewes and 84.5% in hoggets. No marked seasonal fluctuation was observed. The serological findings, in addition to the fact that one splenectomised lamb reacted to larval infestation with acute ovine babesiosis, show that the preimaginal stages of R. bursa occurring in the winter can transmit B. ovis, usually causing a sub-clinical disease. This might play a major role in pre-immunizing and strengthening the premunition of the sheep against the main spring challenge by the adult ticks. The sub-clinical reactions are probably due to the low infection rate of the preimaginal stages of R. bursa by B. ovis parasites.
 ...
PMID:Some epizootiological and clinical aspects of ovine babesiosis caused by Babesia ovis--a review. 956 3

Clinical, clinico-pathological and serological studies were performed in sheep experimentally infected with Babesia ovis. Acute babesiosis occurred in all the lambs infested with adult Rhipicephalus bursa ticks and in one lamb infested with the larvae. The rate of parasitaemia and the degree of anaemia were not correlated. Decrease in the packed-cell volume ranged from 30 to 40%. Parasitized erythrocytes were not observed to block capillaries in the brain, which explained the absence of nervous symptoms in acute babesiosis. The kidneys were the most severely affected organs, exhibiting acute glomerulonephritis. The lesions observed were suggestive of vascular alteration and vascular stasis, leading to anoxia of the tissues. A disseminated intravascular coagulation (DIC) syndrome was recorded in sheep infected with babesiosis. A marked increase in the enzymes of the transaminase groups, mainly aspartate aminotransferase (AST), was observed. Enzymatic changes (increases in AST, alanine aminotransferase (ALT) and lactic dehydrogenase (LDH) and decreases in sorbitol dehydrogenase (SDH), alkaline phosphatase (ALP) and malic enzyme (MEZ)), decreases in total proteins and albumin, and increases in urea and creatinine might reflect the degree of severity of the damage to the liver and kidney tissues. Most of the lambs (85%) that were infested with larvae, and all lambs infested with adult R. bursa ticks, reacted serologically to B. ovis antigen. The serological reactions following infestation with the larvae occurred much later than those following infestation with the adult stage. The lambs which were infested with larvae showed mild clinical reactions when challenged by infected R. bursa adults, as compared with the reactions to the challenge in naive control animals. The serological findings, in addition to the fact that one splenectomized lamb reacted to larval infestation with acute ovine babesiosis, show that the preimaginal stages of R. bursa can transmit B. ovis, usually causing a sub-clinical disease. It is suggested that infections derived from preimaginal ticks in the winter can preimmunize sheep for the subsequent more severe infections derived from adult ticks in the summer. Furthermore, in the absence of a reliable vaccine against B. ovis, grazing flocks in the enzootic regions should be exposed to the preimaginal stages during their activity period (October-February) before exposure to the adult ticks in spring and summer (April-July).
 ...
PMID:Clinical, clinico-pathological and serological studies of Babesia ovis in experimentally infected sheep. 978 Aug 25