Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The changes in the level of glycated proteins and some factors of coagulation were studied in 30 patients with diabetes mellitus--15 with and 15 without diabetic retinopathy. The mean level of glycoalbumin was elevated (2.9 +/- 0.8 mg) HMF (mg protein) without an authentic difference in the two subgroups. Glycohemoglobin was also increased (means--13.6 +/- 1%) in all studied subjects The activity of antithrombin III was high (means--222 +/- 53%) and the concentration--reduced--means--22.1 +/- 2.2 mg%, without authentic difference in the two subgroups. The concentration of alpha-2-macroglobulin, as well as its activity showed no significant deviations. Factor VIII (von Willebrand) was within reference limits (means--97.04 +/- 15.06%) with a tendency to lower values in the group without diabetic retinopathy. Fibrinogen level (means--4.3 +/- 1.2 g) was within the reference range, and FDP--increased in the majority of the examined. A syndrome of intensified latent coagulability, equivalent to chronic decompensated DIC, determined by the basic dismetabolism and non-enzymatic glycating of proteins has been outlined. The changes are more marked in the cases with diabetic retinopathy.
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PMID:[Glycosylated proteins and various hemostatic indices in diabetic retinopathy]. 244 29

Alpha-2-macroglobulin and fast antiplasmin, the main inhibitors of the fibrinolytic system, and the presence of plasmin-antiplasmin complex (P-AP) were studied in 15 DIC patients and in 20 healthy individuals. There was a lack of correlation between immunological and chromogenic substrates alpha-2 antiplasmin levels when P-AP complex were found in DIC patients (in 6/15 cases). The levels of alpha-2-macroglobulin were within the normal range in most of these patients, confirm the secondary role of this inhibitor in fibrinolysis.
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PMID:Functional activities and concentrations of plasmin inhibitors in normal subjects and D.I.C. patients. 618 Apr 98

We have studied the main protease inhibitors of leukocytes, alpha-1-protease (alpha 1-PI), alpha-1-antichymotrypsin (alpha 1-Achy) and alpha-2-macroglobulin (alpha 2-M), as well as different parameters of coagulation and fibrinolysis in 21 cases of acute nonlymphoblastic leukemia (ANLL) before, during and after therapy. Nine of the patients presented signs of DIC, 8 of whom belonged to subtype M3 and to subtype 1 M1. The initial alpha 1-PI and alpha 1-Achy levels, which were elevated, increased during the treatment period. There was no significant difference between patients with and without DIC. However, those leukemic patients with DIC showed a significant decrease in plasminogen (p less than 0.005) and fast antiplasmin (p less than 0.01) only during the treatment compared with DIC free patients. All DIC cases demonstrated circulating plasmin-antiplasmin complex (P-AP) both before and during treatment. Independent of a possible proteolytic action of leukocyte enzymes on clotting factors in the clinical course of ANLL (mainly M3 subtype), our results suggest an activation of plasmin-mediated fibrinolysis related to the activation of plasminogen by leukocytes, reactive DIC or both.
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PMID:Changes in plasma levels of protease and fibrinolytic inhibitors induced by treatment in acute myeloid leukemia. 623 45

Previous studies suggest that there is a systemic activation of clotting and fibrinolysis in preterm infants with advanced respiratory distress syndrome (RDS). However, there are no data on the hemostatic status in the early stages of the disease; therefore, we studied some of the hemostatic parameters in these patients and made several studies at different times in preterm infants who did or did not develop RDS, using similar protocols. We found normal plasma fibrinogen, protein C, protein S, C4b-binding protein, thrombomodulin, antithrombin III, thrombin-antithrombin III complex, prothrombin fragment 1.2, plasminogen, tissue plasminogen activator, alpha-1 antitrypsin, alpha-2-macroglobulin and protein Z. However, lower D-dimer and higher plasminogen activator inhibitor and von Willebrand factor antigen levels were found within six hours of life in infants who later developed RDS compared to the control group. These findings suggest that disseminated intravascular coagulation is not prominent in the early stages of RDS. Moreover, reduced D-dimer and increased plasminogen activator inhibitor and von Willebrand factor antigen levels are probably related to the abnormalities in the fibrinolytic mechanism due to lung damage in RDS, but further studies are needed to show their pathogenic significance in RDS.
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PMID:Hemostatic system in early respiratory distress syndrome: reduced fibrinolytic state? 1077 Jan 17