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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Disseminated intravascular coagulation (DIC) occurs most frequently during the newborn period. Some clinical and laboratory criteria are available for the diagnosis of DIC in adults. However, they are not necessarily applicable in the diagnosis of DIC in newborn infants since the physiological state of coagulation during the newborn period differs from that in adults. We therefore reviewed 74 cases of DIC in newborns, including 34 cases at our own newborn care units. Criteria for the diagnosis of DIC in newborn infants were established.
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PMID:Diagnosis of DIC in newborn infants. 642 Dec 73

The peak incidence of DIC in the pediatric age group is in the neonatal period. The newborn infant is particularly susceptible to DIC because of several handicaps, such as physiological hypofunction of anticoagulant and fibrinolytic systems, an underdeveloped capacity in the reticuloendothelial system and a tendency to develop acidosis, hypothermia, hypoxia and shock. Although some criteria have been reported for the diagnosis of DIC in adults, based on clinical and laboratory findings, these are not necessarily applicable to the diagnosis of DIC in newborn infants. This is because a large blood sample is required, a long period of time is necessary for assay and difference in several coagulation and fibrinolysis factors exist between newborn infants and adults. We therefore established a criteria for the diagnosis of DIC in newborn infants, based on data obtained from newborn infants with DIC. Diagnostic procedures of many molecular markers of hemostasis have been developed from this. Some of them, such as FDP-D dimer are valuable for the diagnosis in children but others are not necessarily useful because of the susceptibility to the venipuncture technique. Our criteria for the diagnosis of DIC in newborn infants must be modified in the diagnosis of DIC in very low birth weight infants.
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PMID:[New approach to the diagnosis of disseminated intravascular coagulation in childhood]. 843 30

Disseminated intravascular coagulation (DIC) occurs most frequently during the neonatal period. We have already established criteria for the early diagnosis of DIC in newborn infants, based on the analysis of clinical and laboratory findings in neonates with and without DIC. In that study, laboratory findings for subjects without DIC were evaluated based on the results obtained from neonates whose birth weights were more than 1500 g. Accordingly, these criteria are not necessarily applicable to the diagnosis of DIC in very low birth weight infants (VLBWI) since the physiological and pathological states of coagulation and fibrinolysis in VLBWI may differ from those of term newborn infants. Therefore, we measured platelet counts, plasma fibrinogen contents and the fibrin degradation product (D-dimer) concentrations in VLBWI with and without DIC. These findings indicate that the scoring system for platelet counts in our diagnostic criteria of DIC in newborn infants is applicable to the diagnosis of DIC in VLBWI. However, our scoring systems for fibrinogen and D-dimer were not usable for the diagnostic criteria of DIC in VLBWI since fibrinogen and D-dimer concentrations in VLBWI without DIC were lower than those in non-DIC neonates whose birth weights were above 1500 g. We devised criteria for the diagnosis of DIC in VLBWI based on those findings.
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PMID:Diagnosis of DIC in very low birth weight infants. 983 15