Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of a 65-year old female patient is reported, dealing with consumption coagulopathy and secondary hyperfibrinolysis due to cystic spleen. Following treatment with heparin, antifibrinolytic agents and replacement of clotting factors prior to surgery, the patient attained a satisfactory condition to be operated on. After removal of the cystic spleen, which was interspersed with massive hemorrhages, blood coagulation returned to normal quickly and continuously. The pathogenesis of consumption coagulopathy in relation to cystic spleen is discussed and it is referred to the pathomechanism of similar blood disorders in hemangiomatous and cavernous lesions of Kasabach-Merritt-syndrome, Klippel-Trenaunay-syndrome and pachymeningeosis haemorrhagica interna.
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PMID:[Consumption coagulopathy in a case of cystic spleen (author's transl)]. 95 1

Patients with Sturge-Weber disease and Klippel Trenaunay syndrome may have several neurologic abnormalities. The effects of hemangiomas in the brain cortex and the spinal cord are responsible for most of the anesthetic challenges associated with this disease, particularly the risks of intracerebral bleeding, disseminated intravascular coagulation (DIC), and airway management. The successful management of this case illustrates that adequate preparation to handle the possible complications may result in safe anesthetic management in patients with these problems.
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PMID:Anesthesia for patients with Sturge-Weber disease and Klippel-Trenaunay syndrome. 165 59

Reports of Parkes-Weber syndrome complicated by disseminated intravascular coagulation (DIC) are rare in the orthopaedic literature. This is a case report of a 23-year-old man who had this syndrome and who sustained a lower-leg fracture complicated by the DIC. Open reduction was not attempted because the DIC worsened after manual reduction. Amputation was rejected by the patient. Three months of continuous infusion of heparin and replacement therapy with fresh frozen plasma was done. Cast immobilization without further reductions was continued. The DIC improved and union of the fractures was observed at 2 years and 3 months after injury.
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PMID:Lower leg fracture with Parkes-Weber syndrome complicated by disseminated intravascular coagulation. 853 52