Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0012739 (
disseminated intravascular coagulation
)
8,673
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We describe a 31-year-old Japanese female patient with systemic lupus erythematosus (SLE), who developed
disseminated intravascular coagulation
(
DIC
), fever, erythema on the hands, and
aphthous stomatitis
despite the absence of circulating anticoagulant. Since no other cause for
DIC
besides SLE could be demonstrated, she was treated with prednisolone and anticoagulants, which rapidly corrected the
DIC
as well as the other manifestations of SLE. During the episode of
DIC
, elevated serum anti-DNA antibody titers and decreased serum complement concentrations were not observed. In contrast, the serum concentration of soluble CD8 (sCD8) paralleled SLE disease activity. In addition, the concentration of plasma thrombomodulin was also increased. These observations suggest that the serum concentration of sCD8 is related to the clinical aspects of SLE, and that vasculitis might contribute to the development of SLE-associated
DIC
.
...
PMID:Systemic lupus erythematosus complicated by disseminated intravascular coagulation: the role of serum soluble cell surface markers. 944 26
