Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 6-year-old male Doberman Pinscher developed multiple organ infarctions secondary to vegetative endocarditis. Clinical signs included fever, nystagmus, head-tilt, inappetence, dehydration, hematuria, and dysuria. The dog was azotemic and anemic and had a high WBC count and high liver enzyme activities. Disseminated intravascular coagulation was diagnosed on the basis of thrombocytopenia and prolonged activated clotting times. Vegetative mitral valvular lesions were evident on M-mode echocardiography. The dog underwent diuresis with physiologic saline solution and was treated parenterally with antibacterial and anticoagulant agents. Surgery was performed to remove an infarcted kidney and an infarcted spleen and to relieve urethral obstruction caused by a large blood clot. Gram-positive cocci were noticed in the biopsy specimens. Mortality associated with organ infarctions secondary to bacterial endocarditis is high, and combined medical and surgical therapy is rarely reported. This dog survived and was alive 38 months after surgery.
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PMID:Medical and surgical management of multiple organ infarctions secondary to bacterial endocarditis in a dog. 320 56

Although snakebites are frequently seen in small animal practice in South Africa, boomslang (Dispholidus typus) bites are infrequent due to their shy habits. Boomslang venom is a potent procoagulent, causing a consumption coagulopathy and profuse haemorrhage. Boomslang monovalent antivenom is the most effective treatment. This case report describes and discusses 2 small dogs that were presented to a private practice after being bitten by the same boomslang. Boomslang monovalent antivenom administration to both resulted in cessation of bleeding within 45 minutes. One of the dogs developed severe adverse reactions to the antivenom, including vomiting, dyspnoea and nystagmus, which responded well to intravenous cortisone and symptomatic treatment.
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PMID:Boomslang envenomation in 2 dogs in Kwazulu-Natal, South Africa. 1766 67