Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recently cases of tsutsugamushi disease have been reported in various areas in Japan. We met a case infected in a rural area, Sennan of Osaka prefecture. The patient suffered from high fever, left axillary lymphadenitis. At his left elbow an eschar was detected, so tsutsugamushi disease was suspected, despite no rash nor CRP elevation. By indirect immunofluorescence (IF) method, the diagnosis was confirmed. At an early stage (the fifth day after onset) he was followed by probable DIC, remitted successfully by administration of minocycline. For 20 years tsutsugamushi disease has not been reported in Osaka prefecture. This case is the second one and the first child case in Wakayama prefecture. Epidemiologic assessments may need to be investigated in Osaka and Wakayama Prefecture.
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PMID:[The first case of tsutsugamushi disease in 20 years infected in a rural region of Osaka]. 251 27

Six foals were inoculated intrabronchially with a suspension of Corynebacterium equi. Six weeks before this challenge, three foals were vaccinated with a C. equi bacterin. Three foals were unvaccinated controls. All foals developed a severe bronchopneumonia in the inoculated lung, indicating that vaccination was not protective. Three foals (two vaccinated, one control) were killed eight to nine days after infection. One control died on day 9 with lesions of disseminated intravascular coagulation. The remaining two foals (one vaccinated, one control) were killed on day 17. C. equi was cultured in large numbers from affected lung and bronchial lymph nodes, and in smaller numbers from unaffected lung, spleen, and liver in all foals. In the 8- to 9-day-old lung lesions, the alveoli were filled with macrophages, neutrophils, and multinucleate giant cells and most contained numerous C. equi. The few foci of alveolar necrosis were associated with groups of bacteria-laden macrophages undergoing degeneration. In the lesions of 17-day duration, there was extensive parenchymal destruction with little fibrous tissue reaction. Lesions common to both groups included hyperplastic bronchiolitis, pulmonary edema, and perivascular lymphocytic cuffs and a pyogranulomatous lymphadenitis in bronchial nodes. One vaccinated foal had a microscopic pyogranulomatous colitis. The lesions in the experimentally infected foals are compared with those in naturally infected foals and discussed in terms of likely pathogenetic mechanisms involved in C. equi pneumonia in foals.
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PMID:The pathology of experimental Corynebacterium equi infection in foals following intrabronchial challenge. 662 48