Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten patients with severe hematologic malignancies (four with acute leukemia, three with multiple myeloma, one with prolymphocytic leukemia, one with malignant lymphoma and one with blastic crisis of chronic myelogenous leukemia) developed respiratory failure during the period between April 1986 and May 1990. Clinically, the patients manifested high-fever, dyspnea refractory to oxygen therapy, diffuse pulmonary rales and severe hypoxemia without evidence of cardiogenic pulmonary edema. Chest roentgenograms displayed diffuse alveolar infiltrates. Respiratory failure occurred as early as 48 hours and as late as 66 days after the administration of intensive anti-neoplastic chemotherapy. At that time leukocyte count was between 100/microliters and 54,900/microliters. Marked leukocytosis was observed in two patients with AML and PLL. Respiratory failure was preceded by sepsis in one patient with AML and by pneumonia in nine patients. DIC was diagnosed in four patients. All patients treated with high dose methyl prednisolone (mPSL) within 12 hours after the onset of respiratory failure. Only one patient required assisted ventilation. High dose mPSL had significant effect on seven of ten patients. But three patients died from progressive respiratory failure, sepsis, pneumonia and multi-organ failure.
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PMID:[Clinical investigation on acute respiratory failure in patients with severe hematologic malignancy]. 194 22

The serum of a patient with prolymphocytic leukemia and a hyperviscosity syndrome contained high levels of IgM, with a monoclonal peak on protein electrophoresis, and had a high titer for fibrin(ogen) degradation products, using a rabbit anti-fibrinogen reagent, without other evidence for disseminated intravascular coagulation. A monoclonal IgM lambda cryoglobulin was identified. It retained reactivity with the fibrin(ogen) degradation products reagent, but failed to react with human IgG by latex fixation. Binding activity for rabbit IgG (and absence of binding activity for human, goat, and bovine IgG) was also demonstrable by double diffusion in agarose, and by enzyme-linked immunoassay. By enzyme-linked immunoassay, binding of both F(ab)2 and Fab and, to a lesser extent, Fc fragments of rabbit IgG was found. Increased binding of heat-denatured rabbit IgG was observed, without inhibition by similarly denatured IgG of other species. The false-positive fibrin(ogen) degradation products reaction in the serum of this patient was due to a unique monoclonal IgM lambda cryoglobulin with warm-reactive antibody activity for an epitope displayed on native and denatured rabbit IgG, but absent on native or denatured human, goat, or bovine IgG, and present in both F(ab)2 and Fc regions of the IgG molecule.
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PMID:False-positive reaction for fibrin degradation products due to a monoclonal (IgM lambda) cryoglobulin with warm-reactive antibody activity for rabbit IgG. 244 Mar 1