Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0012739 (disseminated intravascular coagulation)
 8,673 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult onset Still's disease was first reported by Bywaters in 1971. It is a systemic inflammatory disorder of unknown etiology, characterized by spiking fever, macular rash and polyarthritis. Although the prognosis is generally good, severe cases have been published. They include those with disseminated intravascular coagulation (DIC), hemophagocytosis, amyloidosis and respiratory failure. Among them, DIC is not uncommon. Prednisolone in a dose of 20-60 mg/day is required when patients fail to respond to nonsteroidal anti-inflammatory drugs (NSAIDs) or when they are accompanied by complications including pleuritis, pericarditis, liver dysfunction, severe arthritis and DIC. Recently, disease-modifying antirheumatic drugs (DMARDs) and immunosuppressive agents including cyclophosphamide and methotrexate have been shown to be effective for alleviating refractory cases and chronic arthritis.
 ...
PMID:[Adult Still's disease]. 1007 10

Combat related injuries bring untold misery to the victims and their loved ones. While injuries to vital organs cause immediate death, delayed mortality after reaching a hospital may occur due to several reasons, rhabdomyolysis or the crush syndrome being the most important. Crush syndrome predominantly affects the kidneys leading to renal failure, but the clinical picture may include acute respiratory distress syndrome, dyselectrolytaemia, disseminated intravascular coagulation, hypovolemic shock, arrhythmias and psychological trauma. Rescue, resuscitation and rehabilitation are onerous tasks and so a coordinated strategy with well trained team of professionals through various chains of evacuation is advocated. This article addresses these issues drawing upon the experience of the writer in combat casualty care in active operations.
...
PMID:Crush Injuries and the Crush Syndrome. 2736 33