Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0012739 (
disseminated intravascular coagulation
)
8,673
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hemorrhagic diathesis is one of the most striking manifestations in acute leptospirosis. Hemorrhages are seen in infections due to Leptospira icterohaemorrhagiae as well as in those caused by Leptospira pomona. Thrombocytopenia is a constant feature and its finding can be useful for the diagnosis. Attempts to demonstrate the presence of a toxin in leptospires were unsuccessful. A few years ago, a syndrome of
disseminated intravascular coagulation
was associated with the physiopathogenesis of experimental leptospirosis with L. icterohaemorrhagiae. More recently, this syndrome was identified in cases of human leptospirosis and in hamsters infected with L. pomona. It appears now that other spirochetal infections (
borreliosis
) have a similar pathogenesis. Nonetheless, many points are still unclear: the primary cause of
disseminated intravascular coagulation
is unknown, as well as the virulence factors of spirochetes. Some points favor the presence of a toxic factor in leptospires: vascular damage that occurs in the absence of leptospires in damaged areas and the fact that antibiotic therapy is ineffective unless treatment is initiated early in the disease.
...
PMID:A minireview of the pathogenesis of acute leptospirosis. 704 15
The terminal changes following Borrelia duttoni infection in mice consisted of
disseminated intravascular coagulation
with associated depression in temperature, and in white cell and platelet counts with the development of a positive limulus lysate test. Apart from thrombosis and haemorrhage, similar changes were found in mice given cyclophosphamide prior to infection. The results suggest that neither intravascular coagulation nor immune complex formation are major factors in causing death in
borreliosis
.
...
PMID:Terminal changes in mice experimentally infected with Borrelia duttoni. 736 74
