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Query: UMLS:C0011991 (diarrhea)
 57,543 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty patients with severe pustular and cystic acne were treated for prolonged periods with clindamycin (150 mg to 300 mg daily). The average duration of therapy was five months, with 18 patients being treated for more than six months. Only two (3.4%) patients developed mild diarrhea, which was rapidly reversible on discontinuance of the drug. No other adverse reactions were observed. These data suggest that long-term, low-dose clindamycin therapy may be safe for severe pustular of cystic acne.
Arch Dermatol 1976 Jan
PMID:The safety of long-term clindamycin therapy for acne. 12 34

A review of seventy matched acne patients on clindamycin and seventy-two on tetracycline shows that nine patients on clindamycin had diarrhoea whereas no patients on tetracycline had any side effect; no frank pseudomembranous colitis was seen. Although we heed the side effects of clindamycin, it should not be withheld from patients with severe and resistant acne.
Br J Dermatol 1976 Mar
PMID:The unwanted effects of clindamycin in acne. 13 Jan 62

A double-blind prospective study was undertaken to compare low-dosage tetracycline hydrochloride and clindamycin hydrate hydrochloride in the treatment of patients with pustular acne. Clinical improvement was noted in 93.7% of those receiving tetracycline and in 92.8% of those receiving clindamycin. Of those patients who were receiving clindamycin, two patients developed diarrhea and one patient developed pseudomembranous colitis. We conclude, therefore, that clindamycin should not be used as a primary drug in the treatment of acne.
Arch Dermatol 1976 Jul
PMID:Acne vulgaris: double-blind trial comparing tetracycline and clindamycin. 13 2

Eighty-three patients with moderately severe acne were entered into a double-blind study utilizing clindamycin and placebo. Counts of comedones and pustules were made at intervals during a 13-week period. Clindamycin resulted in noticeable improvement of acne in 85% of subjects while in the placebo group improvement was present in 38%. There was also an unexplained reduction of total comedone count in the clindamycin-treated group. Severe side effects occurred in two of 44 patients receiving clindamycin (diarrhea, 1 and rash, 1); although an additional eight patients receiving clindamycin experienced mild diarrhea, discontinuation of therapy was not required. Clindamycin appears to be a valuable additional drug in the treatment of acne.
Arch Dermatol 1975 Aug
PMID:Clindamycin vs placebo as adjunctive therapy in moderately severe acne. 13 70

The effects of orally administered zinc sulfate in 52 patients with mild to moderate acne vulgaris were compared to those of a placebo capsule. The numbers of comedones, papules, pustules, infiltrates, and cysts were counted at each visit over a 12-week period. Forty patients completed the study. Zinc appeared to have a somewhat beneficial effect on pustules but not on comedones, papules, infiltrates, or cysts. Fourteen patients (50%) in the zinc group had side effects of nausea, vomiting, or diarrhea. Six patients (21%) in the zinc group could not tolerate the nausea and withdrew from the study.
Arch Dermatol 1978 Dec
PMID:Zinc sulfate in acne vulgaris. 15 30

A laboratory technician developed allergic contact dermatitis to hydroxyethylmethacrylate associated with nausea, diarrhoea and persistent paresthesiae of the fingertips. The gastrointestinal symptoms were reproduced by patch testing. Hydroxyethylmethacrylate was demonstrated to pass through vinyl gloves. Cross reactions occurred to methyl-, ethyl-, propyl- and isopropylmethacrylate but not to butyl- or isobutylmethacrylate.
Br J Dermatol 1979 Apr
PMID:Contact dermatitis and gastrointestinal symptoms from hydroxyethylmethacrylate. 15 54

Most of cutaneous hereditary diseases are associated with digestive symptoms but only four groups have a predominated digestive symptomatology: I. Hereditary disease with intestinal polyposis. II. Vascular dysplasias with intestinal haemorrhage. III. Connective tissue discover in hereditary diseases. IV. Acrodermatitis enteropathica with diarrhoea. Though very different with one another, Peutz-Jeghers syndrome and Gardner's syndrome are transmitted according to autosomal dominant trait. Only bi- or unigenic origin is still controversed. Rendu-Osler's disease and blue rubber bled naevus also transmit according to autosomal dominant trait. Pseudoxanthoma elasticum is very likely transmitted according to autosomal recessivity. But the main forms of Ehlers-Danlos disease are autosomal dominant conditions, the other form being either autosomal recessive or sex-linked (type V). Acrodermatitis enteropathica is transmitted according to autosomal recessivity but the gene has a very variable penetrance so that the mutations are very common.
Ann Dermatol Venereol 1979 Jan
PMID:[Genetics of hereditary cutaneous diseases associated with digestive tract involvement]. 38 73

The efficacy of orally administered mycophenolic acid (MPA), an inhibitor of guanosine monophosphate (GMP) synthesis, for the treatment of psoriasis, was studied in a double-blind fashion. Of twenty-one patients completing the study period, ten of eleven patients treated with MPA had a greater than 25% decrease in severity score compared with only two of ten patients treated with placebo. The placebo group had a slight increase in severity score compared to almost 50% reduction in the average severity score of the MPA-treated group. After termination of the double-blind portion of the study, the placebo group was treated with MPA and showed a 60% decrease in severity score. Adverse effects encountered included anorexia, nausea, vomiting, and diarrhea. One patient had an uncomplicated episode of herpes zoster. Other than a mild decrease hemoglobin, no hematologic toxicity was noted.
J Am Acad Dermatol 1979 Dec
PMID:Efficacy of mycophenolic acid for the treatment of psoriasis. 39 32

The authors study three rare syndromes which are characterized by the association of cutaneous manifestations with an intestinal polyposis: Gardner's syndrome, Peutz-Jeghers-Touraine's syndrome, Cronkhite-Canada's syndrome. The Gardner's syndrome is transmitted with an autosomal prevalence, and its vital prognosis remains very porr. It is characterized by the association of various cutaneous manifestations such as fibromas, freckles, etc. with osteomas, neuro-fibromas and polyps of the large bowel. Its severity is related to the very early malignant degeneration of digestive polyps. The Peutz-Jeghers-Touraine's syndrome is transmitted in an autosomal prevalence and its vital prognosis is benign. The cutaneous manifestations are the very early occurrence of lentigines on the face, around the hiatus, and on the lips. The polyps are situated on the small bowel, and are the source of important functional phenomenons; their malignant change is rare. The Cronkhite-Canada's syndrome is rare. Its etiology is unknown and its prognosis is very poor. Its manifestation is the association of more or less wide-spread cutaneous pigmentations, alopecia, and onyxis with a digestive syndrome secondary to a pseudo-polyposis which is the origin for afecal and serous diarrhea, a cause for very severe denutrition. The diagnosis and the treatment of these three syndromes are discussed.
Ann Dermatol Venereol 1978 Oct
PMID:[Dermatology and polyposis of the gastro-intestinal tract (author's transl)]. 74 95

Involvement of the large intestine in a long standing case of dystrophic epidermolysis bullosa was characterized by recurrent episodes of diarrhoea synchronizing with exacerbation of the skin lesions. The radiological investigations revealed two narrow segments, one each in the descending and transverse colon, with ulcer craters in the lower part of the former. The haustra from the distal half of the transverse colon to the sigmoid colon were lost.
Br J Dermatol 1977 Apr
PMID:Dystrophic epidermolysis bullosa. Interesting gastro-intestinal manifestations. 86 Nov 75


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