Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011991 (diarrhea)
 57,543 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-seven dogs with lead poisoning were admitted to the University of Pennsylvania Veterinary Hospital from July, 1963, to April, 1975. The major source of the lead was paint. A common history was ingestion of plaster or paint scrapings during room renovation. Most of the dogs were less than 1 year old and had clinical signs referable to the gastrointestinal or the nervous system, or both. The gastrointestinal signs, in order of frequency, were vomiting, anorexia, tender abdomen, diarrhea, and constipation. The neurologic signs, in order of frequency, were hysteria, convulsions, ataxia, blindness, and mydriasis. The finding of many nucleated erythrocytes without severe anemia was nearly pathognomonic for lead poisoning. Of 14 affected dogs subjected to abdominal radiography, 9 had evidence of ingested radiopaque material. A mean blood lead concentration of 18.8 mug/100 ml, with a range of 0 to 50 mug/100 ml, was found for 26 dogs that were hospitalized for problems unrelated to lead poisoning. Of the 27 dogs with lead poisoning, 22 had their blood analyzed for lead. This group had blood lead values ranging from 40 to 530 mug/100 ml. Seven of the affected dogs were monitored throughout their period of treatment with calcium ethylenediaminetetraacetate. The concentration of lead in the blood decreased quickly after the initiation of treatment but leveled off after 2 or 3 days. The initial rapid phase probably corresponded to the removal of weakly bound or extracellular lead, whereas the slow phase probably corresponded to strongly bound or intracellular lead.
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PMID:Lead poisoning in dogs at the University of Pennsylvania Veterinary Hospital. 81 31

As various chemotherapeutic agents are added to treatment routines, the possibility of adverse effects is appreciably increased, particularly in those organs for which the agents have specific toxicity. Symptoms most commonly associated with radiation sickness, such as malaise, anorexia, nausea, vomiting, diarrhea, dysphagia, dermatitis, and depleted hemopoietic elements, are usually seen late in the course of radiation therapy or shortly thereafter. Consequently, they are managed by the physician in charge of radiation or the patient's referring physician. The general physician may be concerned with symptoms arising from delayed organ pathology. These symptoms may arise in many tissues that are still considered somewhat radioresistant, but secondary to sequelae arising because of connective tissue changes from obliterative narrowing of the finer vasculature. Radiation may be only one of several possible causes, and the symptoms of sequelae may appear only after a long latent period, so that the previous radiation may not be considered in the differential diagnosis unless a detailed history is taken. The medical management of these sequelae is, in general, similar to that used for the pathology produced in these organs by other agents.
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PMID:Sequelae of abdominal radiation and their medical management. 83 56

A mortality in muscovy ducklings caused by infection with the intestinal fluke, S. globulus, is described. The disease was characterised by depression, anorexia, wasting, diarrhoea and high mortality. The major pathological lesions were associated with the attachment sites of the flukes and consisted of severe enteritis with ulceration, principally affecting the jejunum, but also involving the duodenum and ileum. Experimental infections were produced in ducklings by oral administration of either G. austrialis infected with S. globulus metacercariae or S. globulus metacercariae or S. globulus metacercariae. The small, dextral, operculate snail G. australis was identified as the intermediate host and G. australis and an unidentified planorbid as transport hosts. L. tomentosa was also able to be a transport host. The epidemiology of the outbreak and aspects of acquired resistance are presented.
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PMID:The occurrence of the intestinal fluke Sphaeridiotrema globulus in domestic ducks in New South Wales. 84 14

Giant hypertrophic gastritis is a newly recognized disease of adult Baseji dogs similar to Menetrier's disease of man. It is characterized by weight loss, diarrhea, dry coat, pale membranes, anorexia, raised convoluted rugae in the body of the stomach, palpable fluid- and gas-filled intestines, colonic inflammation, and radiographically demonstrable dilated intestinal loops. Laboratory findings include leukocytosis, neutrophilia, low hemoglobin, hypoalbuminemia, hypobetaglobulinemia, hypergammaglobulinemia, decreased serum fatty acids, hypocholesterolemia, indicanuria, low fecal pH, and increased fecal fat and nitrogen. Four dogs studied had gastritis with hypertrophy and diffuse lymphocytosis and plasmacytosis of the small intestine.
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PMID:Giant hypertrophic gastritis of Basenji dogs. 85 Sep 91

The diagnosis of Crohn's disease in 13 patients (ten females and three males) at the Howard University Hospital during the ten-year period, 1965-1975, is examined. The most common presenting symptoms were right lower quadrant (RLQ) pain, diarrhea, anorexia, weight loss, and vomiting, while the most common physical finding was RLQ tenderness. Ileocolic involvement occurred most frequently. Eight patients had surgical resection. The most frequent operation was ileocolic resection with ileo-ascending colostomy. The chief indications for surgery were: (1) presumed appendicitis, (2) intestinal obstruction, and (3) internal fistulae.Crohn's disease seems to occur in blacks much less frequently than in whites. When compared to series of white patients reported by others, the series studied here has more females and more ileocolic involvement. In most other series, the greatest involvement is in the "ileum only" group.
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PMID:Crohn's disease in black patients. 85 35

Twenty-eight Friesland calves were infested at 7 to 11 months of age with 5 000-45 OOO cercariae of Schistosoma mattheei. At 7 to 8 weeks post-infestation the majority developed an acute intestinal syndrome characterised by diarrhoea or dysentery, anorexia and loss of condition, from which they recovered spontansously. The severity and duration of illness was proportional to the level of infestation. Two heavily infested animals on a low plan of nutrition developed a subacute syndrome in which the initial acute disease was succeeded by prolonged unthriftiness, without diarrhoea, from which recovery occurred when the nutritional status was improved. Both acute and subacute forms of the syndrome were encountered in natural outbreaks.
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PMID:Schistosoma mettheei infestation in the ox: the intestinal syndrome. 87 50

Bacterial endocarditis caused by Actinobacillus actinomycetemcomitans is a rare disease. A 48-year-old man who had a Starr-Edwards aortic valve prosthesis inserted in 1972 was admitted for evaluation of confusion, headaches, anorexia, weight loss, diarrhea and weakness. Six blood cultures yielded gram-negative organisms which were subsequently identified as A. actinomycetemcomitans. Treatment with ampicillin and gentamicin resulted in cure which has been maintained after an observation period of eleven months. This represents the second report of A. actinomycetemcomitans endocarditis in a patient with a prosthetic valve.
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PMID:Actinobacillus actinomycetemcomitans endocarditis in a patient with a prosthetic aortic valve. 88 Dec 58

Infection of pigs by the whipworm (Trichuris suis) resulted in profuse diarrhea on postinfection days 17 to 21. Anorexia, retardation of growth, dehydration, and emaciation were observed in infected pigs. Scanning electron micrography showed nematodes embedded in the mucosa of the cecum and colon, with resultant disruption of the mucosa. Infected pigs had decreased values of albumin, amylase, calcium and creatine phosphokinase, but increased values of alpha-, beta-, and gamma- globulins, total iron-binding capacity, copper, potassium, uric acid, and aspartate aminotransferase.
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PMID:Pathophysiology of swine trichuriasis. 88 15

An outbreak of acute enteric paramphistomiasis was observed among Yankasa (indigenous) sheep that were herded with cattle on the University farm at Samaru in February 1973. Mortality was approximately thirty to forty per cent. The most important clinical signs were anorexia, unthriftiness and profuse foetid diarrhoea soiling the perianal region and hind legs. Diagnosis was based on the post-mortem findings, clinical signs and presence of conical flukes identified as Paramphistomum microbothrium.
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PMID:Enteric paramphistomiasis in Yankasa sheep. 90 85

Fourteen cases of oak poisoning were diagnosed at the Ohio Veterinary Diagnostic Laboratory, Reynoldsburg, Oh, in the fall of 1976. The poisoning was attributed to ingestion of oak shrubs, oak leaves, and acorns. Clinical signs included anorexia, rumen atony, hemorrhagic diarrhea, subcutaneous edema, and abnormal renal function. Perirenal edema and hemorrhage, ascites, hydrothorax, and hemorrhagic enteritis were frequently encountered pathologic changes. Histologic examination of the kidney revealed multifocal necrosis of the proximal convoluted tubules, which is a characteristic feature of this type of poisoning.
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PMID:Oak poisoning of cattle in Ohio. 91 91


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