Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011881 (diabetic nephropathy)
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Human Gene/Protein
PP13439 11.5
OR2L8 11.5
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase 11.5
Eukaryotic translation initiation factor 4A, isoform 2 11.5
CTNNBIP1 protein 11.5
ANKRD56 11.5
SET domain-containing protein 6 11.5
FLJ00279 11.5
carnosinase 1 10.9
MIOX protein 10.5
OR2AK2 10.5
LGP1 10.5
Engulfment and cell motility protein 1 10.5
SFRS15 10.5
bone morphogenic protein type II receptor 10.5
CNDP1 10.4
UbA52 10.2
ZNF236 10.2
FRMD3 10.1
engulfment and cell motility 1 10.0
TMEM212 9.9
Endosulfine alpha 9.9
C6orf167 9.9
IHG-1 9.9
hemicentin 1 9.9
ALDR1 9.9
TCEAL6 9.9
MFAP3 9.9
forkhead box O4 9.7
GPR149 9.5
TGFR-3 9.5
Homeodomain interacting protein kinase 2 9.5
PLEKHH2 9.5
collagen, type IV, alpha 1 9.2
MAPK organizer 1 9.2
myosin, heavy chain 9, non-muscle 9.2
FAM101A 9.2
TTC39C 9.2
APOL3 9.2
Small ubiquitin-like modifier 4 9.2
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Disease
Chronic proliferative glomerulonephritis 11.5
nephropathy; hereditary 11.5
Hypercholesterolemia aggravated 11.5
diabetic nephropathy 11.5
Nodular diabetic glomerulosclerosis 11.5
Adult Fanconi syndrome 11.5
Renal failure and impairment 11.5
Incipient diabetic nephropathy 10.9
Clinical diabetic nephropathy 10.9
Nodular glomerulosclerosis 10.4
Acute on chronic renal failure 9.9
Residual proteinuria 9.9
GFND 9.9
microalbuminuria 9.6
Microproteinuria 9.5
kidney hypertrophy 9.4
Segmental glomerulosclerosis 9.2
Hepatic calcification 9.2
von Willebrand disease type 2A 8.9
von Willebrand disease type 2A 8.9
hypertensive nephropathy 8.8
Immune complex glomerulonephritis 8.6
nephrosclerosis 8.6
IDDM6 8.5
Diabetic cystopathy 8.5
Lipoatrophic diabetes 8.5
Armanni-Ebstein lesion 8.5
Penile necrosis 8.4
Nephroangiosclerosis 8.4
chronic glomerulonephritis 8.3
glomerulosclerosis 8.3
Diabetic complications 8.2
Mesangioproliferative glomerulonephritis 8.2
IDDM10 8.1
Proliferative retinopathy 8.0
Diabetic microangiopathy 8.0
Uremic pericarditis 7.9
congenital hyperbilirubinemia 7.8
renal disease 7.8
Henoch-Schoenlein nephritis 7.7
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Symptom
excessive urination 7.5
KIDNEY 7.5
polyuria 4.9
ketonuria 4.4
acid regurgitation 4.1
abdominal fullness 3.8
asterixis 3.8
pedal edema 3.8
hypoproteinemia 3.7
disturbed balance 3.7
oliguria 3.5
Decreased activity 3.5
polydipsia 3.4
non-productive cough 3.4
lassitude 3.4
Gastrointestinal symptoms 3.3
urinary frequency 2.4
mental fatigue 2.3
limb pain 2.1
chorea 2.1
renal colic 1.9
dysuria 1.8
cough 1.8
consciousness disturbance 1.8
angina 1.8
alexithymia 1.8
shortness of breath 1.8
hip pain 1.7
muscle cramps 1.7
overweight 1.6
fever of unknown origin 1.5
hypersomnia 1.5
productive cough 1.4
decreased appetite 1.3
bradykinesia 1.3
night sweats 1.3
numbness 1.2
tonic-clonic seizure 1.2
cachexia 1.1
thinning 0.9
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Drug
Caprylic Acid 11.5
Ibrolipim 11.5
Dilazep dihydrochloride 9.9
Succinic Acid 9.9
Imidapril hydrochloride 9.2
Mudanpi 9.2
Pyridoxamine 9.0
Monopril 8.7
Avapro 8.7
Camostat mesilate 8.7
Lotrel 8.4
Gliquidone 8.4
Amiloride hydrochloride 8.4
Aliskiren 8.1
Benfotiamine 8.0
Aliskiren fumarate 7.9
Fosinopril sodium 7.8
Alacepril 7.8
Benazepril hydrochloride 7.4
Medalist 7.4
Ramipril 7.1
Micardis 7.1
Nitecapone 7.1
Omacor 7.0
Bindarit 7.0
Magnolia bark 7.0
Aminoguanidine 7.0
Epalrestat 6.9
Arachidonic Acid 6.9
Olmesartan 6.8
Muzolimine 6.7
Tallow 6.7
Olmesartan medoxomil 6.7
Losartan potassium 6.6
Beraprost sodium 6.5
Cinnamon oil 6.5
Januvia 6.2
Trandolapril 6.2
Ponalrestat 6.1
Norvasc 6.1
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Enzyme
serum carnosinase 9.1
carnosinase 8.7
meprin B 7.6
HK2 7.4
myo-inositol oxygenase 7.2
EC 2.4.2.26 7.1
5,10-methenyltetrahydrofolate synthetase 7.0
NSY 6.7
calpain 10 6.5
aldose reductase 6.4
carnosine synthetase 6.3
pantetheinase 6.3
ACE 6.3
aspartyl aminopeptidase 6.2
renin 6.0
dimethylarginine dimethylaminohydrolase 5.8
beta-D-fucosidase 5.5
FPS 5.4
3-hydroxy-3-methylglutaryl-CoA lyase 5.2
thrombin-activatable fibrinolysis inhibitor 5.1
NADPH oxidase 5.1
AMP-activated kinase 5.0
NADPH oxidase 5.0
neurolysin 5.0
prolyl-tRNA synthetase 4.8
angiotensin-converting enzyme 2 4.8
ketohexokinase 4.8
alanine aminopeptidase 4.8
meprin 4.7
proteinase-3 4.7
eEF2 kinase 4.6
chymase 4.6
nucleotide pyrophosphatase 4.6
AGT 4.5
GTP cyclohydrolase I 4.5
GLO 4.4
tissue kallikrein 4.4
aminopeptidase A 4.4
hepsin 4.3
hepsin 4.3
more...
Compound
C8H12N2O2 10.5
C20H18NO4 10.5
Dilazep dihydrochloride 9.9
SN 46 9.9
Sequoyitol 9.9
C20H18NO4 9.9
Skimmin 9.9
Berberine iodide 9.5
Irbesartan 9.2
Pyridoxamine 9.0
Dihydrochalcone 8.2
Plantamajoside 8.2
Taraxerol 8.1
Taraxerol 8.1
Calmagite 8.1
1,5-isoquinolinediol 8.1
Diiodothyronine 7.9
DJP 7.9
4-hydroxyphenyl acetate 7.8
Lithospermic acid 7.8
Benazepril 7.7
C3H7NO2 7.7
Obacunone 7.7
STZ 7.6
Homocarnosine 7.5
Rhaponticin 7.4
Telmisartan 7.4
Notoginsenoside R1 7.4
Isobavachalcone 7.4
Spinasterol 7.3
Thiazolidinedione 7.2
EPA ethyl ester 7.2
Sennoside A 7.0
AGE 7.0
Cystine 7.0
Farrerol 6.9
TDGA 6.9
Moexipril 6.9
Rhein 6.8
Hordenine 6.8
more...