Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011881 (
diabetic nephropathy
)
10,836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TSC-22
is a leucine zipper transcriptional factor and expression of the
TSC-22
gene is highly induced by TGF-beta treatment. We estimated the frequency of the -396 A/G polymorphism of the
TSC-22
gene with an Alu I-Restriction fragment length polymorphism (RFLP) method in 498 Japanese subjects with type 2 diabetes mellitus. We also determined the promoter activity. The diabetic patients with the AA genotype had a significantly higher incidence of the
diabetic nephropathy
(vs. the AG genotype, P<0.05, odds ratio: 1.95; 95% confidence intervals 1.14-3.33). There was no significant difference in the promoter activity between the fragments with -396A and -396G. These findings suggest that the
TSC-22
gene (-396) A allele is associated with an increasing risk of the
diabetic nephropathy
.
...
PMID:The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy. 1275 81
