Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
Compound
Query: UMLS:C0011881 (
diabetic nephropathy
)
10,836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kidney disease is a major complication of diabetes, and poor glycemic control is associated with the development of
diabetic nephropathy
. The precise mechanisms that lead to diabetic kidney disease still remain largely unknown and are under current investigation. Because glucose transporters in the kidney play an important role in the local maintenance of intracellular glucose and plasma glucose homeostasis, the tissue distribution and regulation of glucose transporter
GLUT8
, a new member of the glucose transporter family with important functions in cellular survival, were examined. To understand the normal regulation of
GLUT8
expression in response to metabolic signals, fasting and feeding conditions were studied. Additionally,
GLUT8
expression was studied using two different models of insulin resistance, GLUT4-/- and db/db mice.
GLUT8
was localized to glomerular podocytes and tubular epithelial cells in the distal portion of the nephron. Expression of
GLUT8
in the kidney was influenced by plasma glucose levels in vivo. Podocytes in kidneys of diabetic db/db mice express higher levels of
GLUT8
compared with nondiabetic db/m mice. Because podocytes play an important role in glomerulosclerosis development and high levels of glucose have been shown to induce apoptotic cell death in various kidney cells, these data may provide further insight into the pathogenesis of glomerulosclerosis and
diabetic nephropathy
.
...
PMID:Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions. 1574 7
