Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011881 (diabetic nephropathy)
 10,836 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetic mellitus. Its treatment by now is mainly focused on the suppression of the renin-angiotonin system and the control of relative risk factors such as hypertension, hyperglycemia and so on, whose effectiveness is disappointed. Stem cells can be found in almost all organs and tissues, the main functional characteristics of stem cells are their capacity for self-renewal, the differentiation into several other cell types, and their immunomodulatory ability. In this article, we review the potential of stem cells as new therapeutic agents in the treatment of DN, discuss about how the diabetic environment affects these cells, and the therapeutic benefits that these stem cells offer for treating DN, suggesting that stem cells therapies might represent a new and promising strategy for the treatment of DN.
Beijing Da Xue Xue Bao Yi Xue Ban 2013 Jun 18
PMID:[Stem cells and diabetic nephropathy]. 2377 38

Mesenchymal stem cell (MSC) can differentiate into multiple lines in various tissues. MSC has the advantage of congenital hypoimmunogenicity and can interact with both innate and adaptive immunocytes, exerting immunoregulatory function via direct cell-cell contact and secreting soluble factors. It also can migrate to tissue injury sites to dampen inflammatory reactions. MSC can be potentially applied to treat immunological and inflammatory diseases, such as acute renal injury, immune kidney diseases, diabetic nephropathy and end-stage renal diseases. This review summarizes the biological characteristics of MSC and the prospects of its application in treatment of renal diseases.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2014 May
PMID:[Research advances on immunoregulation and anti-inflammation function of mesenchymal stem cells and their application in treatment of renal diseases]. 2499 64

We analyzed the characters of Sagliker syndrome by reporting a case of Sagliker syndrome and reviewed literature. We found that Sagliker syndrome had low incidence rate, young onset age, and was more common in women. There were high levels of alkaline phosphatase and parathyroid hormone in the blood of the patients. Patients with Sagliker syndrome with primary onset of non-diabetic nephropathy usually had chronic glomerulonephritis. We thought that secondary hyperparathyroidism in patients with Sagliker syndrome was induced by parathyroid hyperplasia, but high levels of alkaline phosphatase and parathyroid hormone in the blood of the patients with the secondary hyperparathyroidism were the main cause of Sagliker syndrome. Parathyroidectomy could stop the progress of Sagliker syndrome, but it could not reverse the occurrence of skeletal malformation.
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2014 Oct
PMID:[A case of Sagliker syndrome and literature review]. 2535 64