Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011881 (
diabetic nephropathy
)
10,836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Artemisinin
(
Art
) plays a renoprotective role in
diabetic nephropathy
(DN) rats. However, the differential gene expression profile and underlying molecular mechanism of
Art
treatment in DN is not well understood. We constructed an animal model of DN by injection of streptozotocin (STZ) in rats. We then examined the profile of differentially expressed genes following administration of
Art
using RNA-sequencing (KANGCH&EN, Shanghai, China). Five genes identified by RNA-sequencing were randomly selected and validated by qRT-PCR. Bioinformatic analyses were performed to study these differentially expressed genes. We identified a total of 31 genes that were significantly up-regulated in DN samples compared to both normal and
Art
treatment samples, and 38 genes that were significantly down-regulated in DN samples compared to both normal and
Art
treatment samples. The identified genes were associated with a list of gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and may be involved in the mechanism underlying
Art
treatment of DN. Thus, the results from the current study demonstrate that genes are aberrantly expressed after
Art
treatment and identify promising targets in the treatment of DN with artemisinin.
...
PMID:Transcription profiling of artemisinin-treated diabetic nephropathy rats using high-throughput sequencing. 3068 45
