Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011881 (diabetic nephropathy)
 10,836 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of diabetes mellitus (DM). TCM treatment has certain advantages of less toxicity and/or side effects, and herbs could provide multiple therapeutic effects. Berberine (BBR) is a classical natural medicine. In this review, we summarize the application of BBR in the treatment of DM from two aspects. First, modern pharmacological effects of BBR on glucose metabolism are summarized, such as improving insulin resistance, promoting insulin secretion, inhibiting gluconeogenesis in liver, stimulating glycolysis in peripheral tissue cells, modulating gut microbiota, reducing intestinal absorption of glucose, and regulating lipid metabolism. BBR is used to treat diabetic nephropathy (DPN), diabetic neuropathy (DN), and diabetic cardiomyopathy due to its antioxidant and anti-inflammatory activities. Second, the clinical application of BBR is reviewed, such as listing some clinical trials on the effectiveness and safety of BBR, explaining applicable stage and syndrome, the reasonable dose and dose formulation, and the toxicity and/or side effects. This review provides scientific evidence about BBR, as well as introducing some traditional Chinese medical theory and clinical experience, in order to guide clinician to use BBR more suitably and reasonably.
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PMID:Application of berberine on treating type 2 diabetes mellitus. 2586 Dec 68

Berberine (BBR) is a type of alkaloids isolated from Coptidis Rhizoma and Phellodendri Chinensis Cortex and has been used to treat bacterial gastroenteritis, diarrhea and other digestive diseases for more than 1 000 years. According to recent studies, berberine has been found to have multiple pharmacological activities, including lowering blood glucose and lipid, anti-inflammation, antioxidation, relieving type 2 diabetic nephropathy (DN), diabetic cardiovascular disease, diabetic peripheral neuropathy ( DPN) and other complications. In this article, the authors summarized the literature reports about the effects of BBR in lowering blood glucose and preventing and treating the above type 2 diabetes and its complications, in order to provide reference to further studies and promotion of BBR's application.
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PMID:[Effect of berberine in treating type 2 diabetes mellitus and complications and its relevant mechanisms]. 2632 25

Diabetic nephropathy (DN) and peripheral neuropathy (DPN) are unpredictable diabetic complications with narrow management alternatives. CD40-CD40 ligand system may be an essential pathway for diabetic microvascular complications. No previous studies had evaluated the relationship between CD40 rs1883832 polymorphism and DN/DPN. This study aimed to investigate the association between CD40 rs1883832 polymorphism and the risk of nephropathy and neuropathy in Egyptian patients with type 2 diabetes mellitus. A total of 106 diabetic patients (53 with nephropathy and 53 with neuropathy) and 53 healthy controls (without DM or other overt chronic conditions) were recruited from Suez Canal University Hospitals. Genotyping of CD40 gene polymorphisms was carried out using the polymerase chain reaction-restriction fragment length polymorphism assay. Patients with TT genotype and T allele carry a higher risk of developing DN (odds ratio (OR)=5.40, P=0.0026) and OR=2.56, P=0.0009, respectively). Likewise, the risk of DPN was significantly higher in patients carrying TT genotype (OR=2.91, P=0.045) and T allele (OR=1.84, P=0.028), respectively. In conclusions, the T allele is significantly associated with DN and DPN. Further studies with larger sample sizes are necessary to confirm our observations.
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PMID:Association of CD40 rs1883832 Polymorphism with Susceptibility of Diabetic Nephropathy and Neuropathy in Egyptian Population. 3318 Mar 91