Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011881 (diabetic nephropathy)
 10,836 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the effect of pyridoxal-5'-phosphate (PAL-P) on protein glycosylation and diabetic nephropathy in NSY mice. In experiment 1, an in vitro model of the browning phenomenon involving the incubation of lysine and glucose was inhibited by PAL-P. In experiment 2, administration of PAL-P to congenitally diabetic NSY mice markedly reduced the thickening of the glomerular basement membrane. These results suggest that PAL-P has the potential to be used for reducing the nephrotic complications of diabetes mellitus.
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PMID:The in vitro and in vivo inhibition of protein glycosylation and diabetic vascular basement membrane thickening by pyridoxal-5'-phosphate. 191 2

Currently, there is no effective treatment for diabetic microangiopathy. We have been examining, therefore, the effects of lysozyme on the renal conditions of spontaneous diabetic mice (NSY mice). We assessed the changes in glomerulus following the administration of lysozyme, using the thickness of the glomerular capillary basement membrane as an indicator. Littermate, male F19 NSY mice were divided into two groups. One of the groups (Group L) was treated with lysozyme; the other control group (Group C) with physiological saline. Group L received a daily intramuscular injection of lysozyme solution for 4 or 8 weeks. The thickness of the glomerular capillary basement membrane was measured in order to assess the effect of lysozyme administration. In the 4-week series, the thickness was 4783 +/- 1760 A in Group C and 3266 +/- 777 A in Group L, while in the 8-week series it was 6011 +/- 2043 A in Group C and 3540 +/- 431 A in Group L. In both series of Group L, a distinct inhibitory effect on the basement membrane thickening was found. The present findings suggest that lysozyme may be effective in human diabetic nephropathy. However its clinical usefulness must be confirmed in future studies.
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PMID:The inhibitory effect of lysozyme on the glomerular basement membrane thickening in spontaneous diabetic mice (NSY mice). 373 16