Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011881 (diabetic nephropathy)
 10,836 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabetic fatty (ZDF) rats. ZDF rats were fed regular laboratory chow mixed with SP or rosiglitazone (RSG) for an 8-week period. Kidney hypertrophy was developed with increasing plasma glucose level, and glomerular hypertrophy was improved by 22% and 45% in SP- and RSG-treated rats, respectively. Urinary glucose and albumin excretions were also significantly lower in SP-treated rats than in ZDF control rats. Activation of the mitogen-activated protein kinase (MAPK)-transforming growth factor beta1 (TGF beta1)-fibronectin pathway in kidney, responsible for glomerular dysfunction, was markedly blunted by SP treatment in a dose dependent manner. Our findings, for the first time, provide strong evidence that long-term administration of SP formula prevents the development and progression of DN in ZDF rats. Human trials are needed to confirm these experimental results.
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PMID:Long-term administration of Sopungsungi-won (SP) prevents diabetic nephropathy in Zucker diabetic fatty rats. 1251 Aug 48

Megacolon is a congenital disorder. Adult congenital megacolon (ACM), also known as adult Hirschsprung's disease, is rare and frequently manifests as constipation. ACM is caused by the absence of ganglion cells in the submucosa or myenteric plexus of the bowel. Most patients undergo treatment of megacolon at a young age, but certain patients cannot be treated until they develop bowel obstruction in adulthood. Bowel obstruction in adults always occurs in complex clinical situations and it is frequently combined with comorbidities, including bowel tumors, volvulus, hernias, hypertension or diabetes mellitus. Surgical intervention is always required in such cases. To avoid recurrence, a sufficient amount of bowel should be removed, particularly the aganglionic segment. Furthermore, the patient's general physical condition should be considered pre-operatively by controlling parameters including blood pressure and blood glucose. In the present study, a case of ACM combined with fecal impaction and diabetic nephropathy was presented.
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PMID:Adult congenital megacolon with acute fecal obstruction and diabetic nephropathy: A case report. 3157 19