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Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0011881 (
diabetic nephropathy
)
10,836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tuberculous osteomyelitis of sternum after open heart surgery is a
rare disease
entity. We report a case of wound infection with osteomyelitis caused by Mycobacterium tuberculosis in a patient with
diabetic nephropathy
, requiring peritoneal dialysis after coronary artery bypass grafting, who was successfully treated with antituberculous agents and surgical debridement. In addition, we provide a literature review on reported cases of tuberculous sternal osteomyelitis and mediastinitis after open heart surgery, and discuss about the risk factors, clinical features, and treatment of this infection.
...
PMID:Mycobacterium tuberculosis sternal wound infection after open heart surgery: a case report and review of the literature. 1730 Sep 11
The currently available therapies for
diabetic nephropathy
, one of the leading causes of renal failure globally are based on inhibition of renin angiotensin system. However, recently, the focus has shifted towards activation of its protective arm rather than the inhibition of deteriorative axis, using specific agonists. Compound 21 (C21), a novel non-peptide Angiotensin II type 2 receptor (AT
2
) agonist, recently granted orphan drug status for the treatment of a
rare disease
, idiopathic pulmonary fibrosis has also shown a potent anti-inflammatory, anti-fibrotic, antioxidant and anti-apoptotic potential in various diseases including heart failure, myocardial infarction, chronic inflammatory diseases, and neurological diseases such as ischemic stroke. A pool of evidences suggest that C21, either alone or in combination with angiotensin receptor blockers could be extremely beneficial in the treatment of
diabetic nephropathy
, a chronic inflammatory condition sharing its pathogenesis with aforementioned diseases. The review analyses the new therapeutic tool, C21, its mechanisms of action for renoprotection in
diabetic nephropathy
, and its future perspectives and thereby provides an insight into the potential application of C21 as a novel therapeutic tool in the eradication of
diabetic nephropathy
.
...
PMID:AT
2
receptor agonist Compound 21: A silver lining for diabetic nephropathy. 2894 6
