Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011881 (diabetic nephropathy)
 10,836 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study is to clarify stressors resulting from continuous ambulatory peritoneal dialysis (CAPD) in CAPD patients and to discuss adaptation to daily life. With reference to the dialysis stressor scale used by Baldree and Masaki et al., a scale for CAPD stressors, consisting of 42 items, was devised, and the stressors were investigated in 56 patients, with the following results: 1) The items rated as high CAPD stressors included the frequency of bag exchange, itch, fatigue, anxiety about the future, and restricted physical activities. Restriction of meal and fluid intake, which are highly-rated stressors in patients on hemodialysis (HD) were not highly-rated stressors in these 56 CAPD patients. Thus, there was a difference between HD and CAPD. 2) The degree of cognition of CAPD stressors increased according to an individual's situation. (1) The presence or absence of an occupation had the greatest effect on the cognition of CAPD stressors. (2) The degrees of cognition of anxiety about the future and work-related difficulties as stressors were high in patients under 60 years of age. (3) The degree of cognition of items related to work as stressors was high in male patients while that of items related to body image as stressors was high in female patients. (4) There was a qualitative difference in stressor congnition between patients with a history of CAPD of shorter than 3 months and those whose history was 3 months or longer. (5) The degree of congnition of infection was also low in patients who suffered from peritonitis. (6) The degree of congnition of symptoms causing physical discomfort was high in patients with diabetic nephropathy. (7) There were significant differences in several variables, in terms of the degree of congnition, among patients with regard to work difficulties and the absence of familial cooperation. On the basis of these results, guidance for patients and their families is necessary.
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PMID:[Analysis of continuous ambulatory peritoneal dialysis (CAPD) stressors in CAPD patients]. 818 6

Intravenous immune globulin (IVIg) is advocated as a safe treatment for immune-mediated neurologic disease. We reviewed the medical records of 88 patients who were given IVIg for a neurologic illness. Major complications in four patients (4.5%) included congestive heart failure in a patient with polymyositis, hypotension after a recent myocardial infarction, deep venous thrombosis in a bed-bound patient, and acute renal failure with diabetic nephropathy. Other adverse effects included vasomotor symptoms 26, headache 23, rash 5, leukopenia 4, fever 3, neutropenia 1, proteinuria (1.9 g/day) 1, viral syndrome 1, dyspnea 1, and pruritus 1. Fifty-two patients (59%) had some adverse effect of IVIg infusion, most commonly vasomotor symptoms, headaches, fever, or shortness of breath in 40 (45%), which improved with reduced infusion rate or symptomatic medications. Five (6%) had asymptomatic laboratory abnormalities and seven (8%) had other minor adverse effects. Adverse effects led to discontinuation of therapy in 16% and permanent termination of therapy in 10% of patients. There was no mortality or long-term morbidity. Although adverse effects were frequent, serious complications were rare except in patients with heart disease, renal insufficiency, and bed-bound state.
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PMID:Complications of intravenous immune globulin treatment in neurologic disease. 930 72

The term chronic renal failure (CRF) usually means the final stage of chronic kidney disease (CKD) with a decline in glomerular filtration rate (GF) below 0.25 mL/s. CRF is a world-wide serious health and economic issue with an increasing incidence and prevalence. CRF patients are, in comparison to other patients, hospitalized more often and for longer and, despite improvements in care, their quality of life is usually low and morbidity and mortality high. We present an overview of the most important CKD risk factors and the diseases most likely to result in CRF. Diabetic nephropathy, followed by various forms ofischemic renal disease and primary and secondary glomerulopathy, chronic tubulointerstitial nephritis and autosomal dominant polycystic kidney disease are the leading causes of CRF. We provide a brief overview of other disease states that may result in renal failure. Clinical manifestations of CRF are discussed, mainly cardiovascular, gastrointestinal, haematological and neurological symptoms. Breathlessness is a consequence of hypervolaemia, metabolic acidosis and anaemia. The disease often presents with symptoms, such as headache and visual disturbances, resulting from arterial hypertension. Gastrointestinal symptoms and fatigue, usually caused by anaemia, are frequent. Platelet dysfunction is manifested as an increased bleeding time. Paradoxically, apart form tendency to abnormal bleeding, CRF also tends to be associated with thromboembolic complications. Patients may experience itching, bone, joint and muscle aches, are more prone to infections. They may suffer from insomnia, concentration disorders and apathy. The signs of peripheral mixed sensory-motor neuropathy include paraesthesia, paresis and restless leg syndrome. However, renal failure may also be oligosymptomatic or asymptomatic. Cardiovascular complications are the most frequent cause of morbidity and mortality of CRF patients.
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PMID:[Aetiology and a clinical picture of chronic renal failure]. 2187 93

Acquired perforating dermatosis characterised by the transdermal excursion of dermal material which clinically presents as umbilicated skin-coloured papules with a central white crust. A 45 year old male patient with diabetic nephropathy presented with similar lesion and itching. Diagnosis was confirmed by biopsy from appropriate site. Patient responded well to emollients, low dose-retinoids, broad spectrum renal friendly antibiotics and haemodialysis.
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PMID:Acquired perforating dermatosis in a patient of diabetes mellitus with chronic kidney disease. 2585 45

Lisinopril is an angiotensin converting enzyme inhibitor (ACE-I) that has been on market for more than 25 years. ACE-I are usually well tolerated and rarely have serious or life-threatening side effects. We describe an unusual presentation of fulminant hepatic cholestasis probably secondary to lisinopril. To our knowledge, this is the second case report which shows lisinopril-induced liver injury though a cholestatic mechanism. The patient was a 59-year-old woman with type 2 diabetes, a high body mass index and hypertension, who presented with a 5-week history of jaundice and itching. She had been started on lisinopril for diabetic nephropathy 8 weeks before admission. Other causes for cholestasis had been excluded through non-invasive immunology and virology screening, an ultrasound of the liver, magnetic resonance cholangiopancreatography and a liver biopsy. The biopsy was consistent with drug-induced liver injury. Lisinopril was stopped 2 weeks before admission. The patient's hospital stay was complicated by contrast nephropathy and influenza A which were both treated appropriately. Unfortunately, the liver cholestasis did not completely resolve following withdrawal of lisinopril and the patient died after 4 months. A literature search yielded only six other reported cases of lisinopril-induced liver injury. Five cases described hepatocellular damage and one showed cholestatic injury.
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PMID:Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review. 3266 26