Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: UMLS:C0011881 (
diabetic nephropathy
)
10,836
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Excess mesangial extracellular matrix (ECM) and mesangial cell (MC) proliferation is the major pathologic feature of
diabetic nephropathy
.
Kruppel-like factor 15
(
KLF15
) is a member of the KLF transcription factor family that plays a critical role in regulating renal fibrosis. However, the role of
KLF15
in
diabetic nephropathy
remains poorly understood. This study was conducted to explore the role of
KLF15
in the development and progress of
diabetic nephropathy
in high glucose (HG)-stimulated human MCs. Here, we found down-regulated expression of
KLF15
in MCs induced by HG. Overexpression of
KLF15
significantly inhibited MCs proliferation and ECM production induced by HG. Moreover, overexpression of
KLF15
inhibited HG-induced ERK1/2 phosphorylation in MCs. In summary, our data demonstrate that
KLF15
can suppress HG-induced cell proliferation and ECM protein fibronectin expression in human MCs via ERK1/2 MAPK signaling. The results provide evidence that
KLF15
might be a potential molecular target for the treatment of
diabetic nephropathy
.
...
PMID:KLF15 suppresses cell proliferation and extracellular matrix expression in mesangial cells under high glucose. 2688 48
