Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011860 (type 2 diabetes)
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Human Gene/Protein
FLJ39370 9.1
synuclein, gamma 9.1
MRPL30 9.1
cadherin-like 22 9.1
sphingomyelin phosphodiesterase, acid-like 3A 9.1
HERPUD2 9.1
PDX-1 C terminus-interacting factor 1 9.1
ATP-dependent RNA helicase A 9.1
Heat shock 70kDa protein 1B 9.1
engulfment and cell motility 2 9.1
acetylcholinesterase isoform E4-E6 precursor 9.1
C7orf50 9.1
LOC100129150 9.1
CAG-isl 7 9.1
ACACB protein 9.1
neurofilament 3 9.1
LONP 9.1
MODY 9.1
N-acetyltransferase 6 9.1
BCO2 protein 9.1
TMEM217 9.1
C14orf180 9.1
C2orf63 9.1
WDR25 9.1
ATP synthase mitochondrial F1 complex assembly factor 1 9.1
OR2L8 9.1
alcohol dehydrogenase, iron containing, 1 9.1
BTB (POZ) domain containing 3 9.1
ADP-ribosylation factor-like protein 15 9.1
ZNF600 9.1
NIDDM 9.1
FLJ16686 9.1
CSNK2A1 protein 9.1
peroxisomal biogenesis factor 3 9.1
Succinyl-CoA:3-ketoacid-CoA transferase 9.1
R3HDML 9.1
CSRNP2 9.1
actinin, alpha 2 9.1
MCF2L2 9.1
UFSP1 9.1
C14orf73 9.1
MGC21675 9.1
Eukaryotic translation initiation factor 4A, isoform 2 9.1
FAM163B 9.1
Calcium/calmodulin-dependent protein kinase ID 9.1
IHPK1 9.1
OR4F6 9.1
CD97 molecule 9.1
Hematopoietically expressed homeobox 9.1
acyl-CoA synthetase short-chain family member 1 9.1
thioesterase superfamily member 4 9.1
5'-nucleotidase, ecto 9.1
Ankyrin repeat domain 30A 9.1
TIX1 9.1
ZNF239 9.1
Juxtaposed with another zinc finger gene 1 8.5
Endosulfine alpha 8.5
CENTD2 8.5
Zfp69 8.5
TIMM9 8.5
FAM78B 8.5
AP3S2 8.5
SLC16A11 8.5
CDKAL1 8.4
SLC30A8 8.4
ZFAND3 8.4
Transcription factor 7-like 2 8.4
calpain 10 8.4
sodium-glucose cotransporter 8.1
PDCL2 8.1
ubiquitin specific peptidase 10 8.1
DNAJB3 8.1
GYS1 protein 8.1
FAM3A protein 8.1
Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 8.1
CD164L2 8.1
DAB2-interacting protein 8.1
neuron navigator 1 8.1
FAM132A 8.1
HUMPPA 8.1
more...
Disease
Renal adenoma and carcinoma 9.1
type 2 diabetes 9.1
Peripheral and visceral atherosclerosis 9.1
Other biliary tract disorders 9.1
MODY7 9.1
Diabetic mononeuropathy 9.1
NIDDM in obese 9.1
Tropical diabetes 9.1
NIDDM1 8.8
MODY 8.8
Impaired insulin secretion 8.5
Hyperglycemic hyperosmolar nonketotic syndrome 8.5
Other obesity 8.5
NIDDM2 8.5
Latent autoimmune diabetes in adults 8.2
MODY1 8.2
NIDDM3 8.1
MODY6 8.1
Other cardiovascular disease 8.1
Allergic diarrhea 8.1
J type diabetes 8.1
NIDDM4 8.1
Acute necrotizing encephalitis 8.1
Metabolic cardiomyopathy 8.1
MODY2 8.1
MODY3 8.0
MODY4 7.9
DM2 7.9
Autoimmune Diabetes 7.8
Hypertrophic obesity 7.8
prediabetes 7.8
Bladder necrosis 7.5
autoimmune endocrine disorder 7.5
MODY8 7.5
Android obesity 7.5
MRDM 7.5
Metastatic renal carcinoma 7.5
Lancereaux 7.5
Incipient diabetic nephropathy 7.5
IDDM7 7.4
metabolic syndrome X 7.1
protein metabolism disorder 7.1
Drug-induced hypoglycaemia 7.1
Gastrointestinal ulcer 7.1
Sympathicotonia 7.1
endometrial dysplasia 7.1
glucose intolerance 7.0
Bullosis diabeticorum 7.0
Intrauterine malnutrition 6.9
Acquired generalized lipodystrophy 6.9
Alstrom syndrome 6.9
Cardiac autonomic neuropathy 6.8
Senile amyloidosis 6.8
Atypical carcinoid tumor 6.8
Fibrocalculous pancreatic diabetes 6.8
Other metabolic disorders 6.8
Silent myocardial infarction 6.8
Other endocrine disorders 6.8
Diabetic mastopathy 6.8
Diabetic peripheral neuropathy 6.7
Macroangiopathy 6.7
pancreatic islet hyperplasia 6.7
Diabetic macroangiopathy 6.6
Susto 6.6
abdominal obesity 6.6
metabolic syndrome 6.6
microalbuminuria 6.6
Premature adrenarche 6.6
dyslipidemia 6.6
Other liver diseases 6.5
von Willebrand disease type 2A 6.5
alcohol related disorder 6.5
von Willebrand disease type 2A 6.5
Clinical diabetic nephropathy 6.5
Acute endophthalmitis 6.5
hyperglycemia 6.4
PNDM 6.4
Androgen excess 6.4
Diabetic polyneuropathy 6.3
diabetic hyperglycemia 6.3
more...
Symptom
stomach spasm 9.1
KIDNEY 7.4
Burning mouth 7.4
Lancinating pain 7.1
prostatic tenderness 6.3
CVA tenderness 6.3
Early satiety 5.6
Gastrointestinal discomfort 5.5
Night pain 5.5
Musculoskeletal discomfort 5.3
External ophthalmoplegia 5.3
prickling sensation 5.2
overweight 5.2
excessive urination 5.1
ketonuria 4.9
Male sexual dysfunction 4.9
cardiovascular problem 4.6
hemiparesthesia 4.5
Hemiballism 4.5
change in skin color 4.4
cold sweats 4.3
upset stomach 4.2
Climacteric symptoms 4.2
Fatigability 4.1
polydipsia 4.1
reproductive problem 4.0
Tissue sensitivity 4.0
weight problem 4.0
polyuria 3.7
Fear of falling 3.6
Fear of falling 3.6
stomach cramps 3.5
cardialgia 3.4
pedal edema 3.4
physical exhaustion 3.3
Cushingoid 3.3
nipple pain 3.3
nipple pain 3.3
frequent urination 3.3
Catch 3.3
mouth pain 3.2
Poor sleep 3.2
painful swallowing 3.1
renal pain 3.0
hunger 3.0
eye discharge 3.0
pneumaturia 3.0
Cushingoid 3.0
corpulence 2.9
Urinary symptoms 2.9
Multimorbidity 2.8
Depressive symptoms 2.7
male puberty 2.7
Decreased activity 2.6
peau d'orange 2.6
jaw pain 2.6
Lower urinary tract symptoms 2.6
thigh pain 2.5
decreased appetite 2.5
Stepping 2.5
urinary frequency 2.4
hand pain 2.4
Blanching 2.4
Musculoskeletal symptoms 2.4
No adverse effect 2.4
disturbed balance 2.3
bewilderment 2.3
tingling 2.3
nausea 2.2
female puberty 2.2
hyperesthesia 2.1
body pain 2.0
leg edema 2.0
forgetfulness 2.0
menopausal symptoms 2.0
cachexia 2.0
lassitude 2.0
generalized rash 1.9
memory loss 1.9
Wind 1.9
more...
Drug
Glyclopyramide 9.1
Lycium bark 9.1
Temocapril hydrochloride 9.1
Glyset 9.1
Precose 8.5
Symlin 8.2
Tesaglitazar 8.2
Elaszym 8.1
Pyrroloquinoline Quinone 8.1
Exenatide 8.1
Januvia 8.1
Liraglutide 8.0
Colesevelam 7.9
Pramlintide 7.9
Amaryl 7.9
Lantus 7.8
Ertiprotafib 7.8
Actos 7.8
Insulin glargine 7.7
Muraglitazar 7.6
Succinic Acid 7.5
Avandia 7.5
Axokine 7.5
Gliclazide 7.5
Insulin detemir 7.4
Actos 7.4
Alogliptin benzoate 7.3
Avapro 7.3
Dibotin 7.1
Insulin lispro 7.1
Insulin aspart 6.9
Rosiglitazone 6.9
Insulin glulisine 6.9
Sergliflozin 6.8
Trodusquemine 6.8
AG-EE 388 ZW 6.8
Troglitazone 6.7
Voglibose 6.7
Colestimide 6.7
metformin hydrochloride 6.6
Masoprocol 6.5
Starlix 6.5
Secrepan 6.5
Glucagon 6.4
Masoprocol 6.3
Mecasermin rinfabate 6.3
Humalog 6.1
Thyradin 6.1
Tripamide 6.1
Atractylodes lancea rhizome 6.1
ADM 6.0
Orlistat 5.8
BETA-2 5.8
Adenosine Monophosphate 5.8
Hymenialdisine 5.8
AHF 5.7
Perindopril 5.7
Rimonabant 5.6
Lipoic Acid 5.6
Benfotiamine 5.6
Trandolapril 5.5
Humulin 5.5
Gliquidone 5.4
Calcifediol 5.3
Pitavastatin calcium 5.2
Ramipril 5.1
Meridia 5.1
Alrestatin 5.1
Tazorac 5.1
Medalist 4.9
Valsartan 4.9
Olmesartan 4.9
1,2,4-Triazole 4.9
Mosapride citrate 4.8
Myo-Inositol 4.8
Darapladib 4.7
Metreleptin 4.7
Beraprost sodium 4.7
Aliskiren 4.7
Micardis 4.6
more...
Enzyme
calpain 10 8.3
calpain 5 7.5
dipeptidyl-dipeptidase 7.1
calpain 9 7.1
proprotein convertase 2 6.3
glucokinase 6.3
dipeptidyl peptidase IV 6.1
STK13 5.9
NSY 5.8
serum carnosinase 5.6
geranoyl-CoA carboxylase 5.5
ceramide synthetase 5.5
insulin-degrading enzyme 5.3
AMP-activated protein kinase 5.3
AMP-activated kinase 5.2
proprotein convertase 1 5.2
AMPK 5.0
tRNA isopentenyltransferase 5.0
acetate CoA-transferase 4.9
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 4.9
alpha-glucosidase 4.8
carnosinase 4.8
glucose-6-phosphatase 4.7
phosphoenolpyruvate carboxykinase 4.7
EC 2.3.1.4 4.6
3-hydroxyisobutyryl-CoA hydrolase 4.6
5,10-methenyltetrahydrofolate synthetase 4.6
CMP-Neu5Ac hydroxylase 4.6
ketohexokinase 4.4
phosphoenolpyruvate carboxykinase 4.4
phosphoenolpyruvate carboxykinase 4.4
GM3 synthase 4.4
11beta-hydroxysteroid dehydrogenase 4.4
alpha-1,4-glucan lyase 4.4
nicotinamide phosphoribosyltransferase 4.3
methylcrotonyl-CoA carboxylase 4.2
acetyl-CoA carboxylase 4.1
thrombin-activatable fibrinolysis inhibitor 4.1
AMPK 4.1
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.0
LPL 4.0
matrix metalloproteinase 10 4.0
carboxypeptidase E 3.9
FADS 3.9
GPI-PLD 3.9
inositol 3-kinase 3.8
3-hydroxyisobutyrate dehydrogenase 3.8
paraoxonase 3.8
nicotinamide adenine dinucleotide glycohydrolase 3.8
O-GlcNAc transferase 3.7
kynurenine formamidase 3.7
hormone-sensitive lipase 3.7
lipoprotein lipase 3.7
PHOSPHO1 3.6
pyruvate dehydrogenase phosphatase 3.6
carotene 15,15'-dioxygenase 3.6
CYP8B1 3.6
STK2 3.6
diacylglycerol acyltransferase 3.6
nicotinamide N-methyltransferase 3.6
trehalose phosphorylase 3.6
3-hydroxy-3-methylglutaryl coenzyme A reductase 3.5
phosphoglycolate phosphatase 3.5
PDK1 3.5
1-acylglycerol-3-phosphate O-acyltransferase 3.5
aldose reductase 3.5
ACE 3.4
fatty-acid synthase 3.4
fructose 1,6-bisphosphatase 3.4
pyruvate carboxylase 3.4
nucleotide pyrophosphatase 3.4
paraoxonase 3.4
inositol phosphatase 3.3
AICAR transformylase 3.3
renin 3.3
PDH 3.3
phosphofructokinase 1 3.3
GSK 3.2
GP-I 3.2
glucosylceramide synthase 3.2
more...
Compound
2,5-dichloro-2,5-dimethylhexane 9.1
Glutargin 9.1
Hydroxyethyl disulfide 9.1
Linderane 9.1
Sequoyitol 8.5
MOD 8.5
Tolimidone 8.1
propanediimidamide 8.1
1,3-dimethyl-1H-indole 8.1
C17H34O2 8.1
Benzyl chloroformate 8.1
Deuterohemin 8.1
Deuterohemin 8.1
Nateglinide 7.7
Repaglinide 7.7
Glimepiride 7.7
ethyl undecanoate 7.5
Triphenylselenonium chloride 7.5
DPP 7.5
Metformin 7.4
Metformin 7.4
Pioglitazone 7.2
Eburicoic acid 7.1
Miglitol 7.1
Variabilin 7.1
Acetylspiramycin 7.1
Acarbose 7.0
Thiazolidinedione 6.9
Pima 6.8
C18H30O2 6.8
2,2',4,4',5,5'-Hexachlorobiphenyl 6.8
9H-xanthene-9-carboxylic acid 6.8
2-thiophenecarboxamide 6.5
Rutamarin 6.5
N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide 6.5
Irbesartan 6.4
aminomethanesulfonic acid 6.4
Lithospermic acid 6.4
aminomethanesulfonic acid 6.4
Glucagon 6.4
1-phenylethanone 6.4
1-phenylethanone 6.4
1-phenylethanone 6.4
1-phenylethanone 6.4
Biguanide 6.3
14,15-DiHETrE 6.3
Asperuloside 6.3
DG 2 6.3
1,5-AG 6.3
1-phenylethanone 6.2
aminomethanesulfonic acid 6.2
5-methyl-2,4-dihydro-3H-pyrazol-3-one 6.1
Asperuloside 6.1
Laurencin 6.1
aminomethanesulfonic acid 6.1
5,6-DHET 6.1
4-fluorobenzonitrile 6.1
Asperuloside 6.1
Previtamin D3 6.1
C18H12N2 6.1
1-phenylethanone 6.0
Fenofibrate 6.0
dibenzyl phthalate 5.9
4-methyl-1,3-thiazole 5.9
[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 5.9
8,9-DiHETrE 5.9
pentacosanoic acid 5.9
1,3-oxazolidine-2,4-dione 5.9
Sennoside 5.9
Insulin 5.9
Soriatane 5.8
Karanjin 5.8
Fluocinolone 5.8
Sibutramine 5.8
Taraxerol 5.6
(-)-Catechin 5.6
cholestan-3-ol 5.6
aminomalonic acid 5.6
Epicoprostanol 5.6
Taraxerol 5.6
more...