Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0011860 (type 2 diabetes)
57,723 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein insulin 25338 Sep 3496 glucagon 3025 hemoglobin 2655 Mol 2358 NIDDM 2271 HDL 1466 adiponectin 1464 peptidase 1302 gut 1232 leptin 1205 GLP-1 receptor 1204 albumin 1095 insulin receptor 854 cytokine 828 DPP 822 C-reactive protein 781 ATP 749 amylin 742 GLP-1 727 peroxisome proliferator-activated receptor 684 renin 635 endoplasmic reticulum 624 IRS-1 611 TNF 600 peroxisome proliferator-activated receptor gamma 591 tumor necrosis factor 589 IDDM 581 AMP-activated protein kinase 577 IL-6 571 glucokinase 406 glucose transporter 390 GLUT4 384 AMPK 375 DM2 373 adipokine 369 sodium-glucose cotransporter 361 glucosidase 351 Adiponectin 345 interleukin-6 338 resistin 337 mTOR 326 glucose-dependent insulinotropic polypeptide 311 collagen 307 proinsulin 303 superoxide dismutase 294 dipeptidyl peptidase IV 293 angiotensin II 279 MODY 279 PPAR 277 AKT 270 PI3K 257 fibrinogen 239 CRP 235 She 227 INS-1 227 ACE 226 SGLT2 225 AMP 225 nuclear receptor 221 plasminogen activator inhibitor-1 220 catalase 218 caspase-3 214 growth hormone 212 amylase 211 GLP 205 ghrelin 197 protein kinase B 197 TCF7L2 195 apolipoprotein B 193 PGC 191 polypeptide 189 angiotensin receptor 187 alpha-glucosidase 185 STZ 184 GSH 184 phosphatase 181 Leptin 174 Kir6.2 174 MRI 173 more...

Disease type 2 diabetes 57723 diabetes 25264 obesity 13374 hypertension 5481 cardiovascular disease 5277 hyperglycemia 4664 metabolic syndrome 4303 type 1 diabetes 2930 glucose intolerance 2800 hypoglycemia 2448 dyslipidemia 2395 atherosclerosis 2361 cancer 2261 renal disease 1833 hyperinsulinemia 1518 diabetic nephropathy 1441 fatty liver 1277 stroke 1229 Alzheimer's disease 1130 coronary artery disease 1071 hyperlipidemia 1040 coronary heart disease 1028 heart failure 1000 retinopathy 903 myocardial infarction 853 gestational diabetes mellitus 845 prediabetes 786 diabetic retinopathy 712 microalbuminuria 710 depression 684 neuropathy 625 polycystic ovary syndrome 557 chronic disease 530 proteinuria 520 abdominal obesity 503 metabolic disorder 487 tumor 482 cirrhosis 478 vascular disease 459 Nonalcoholic fatty liver 457 cognitive impairment 451 renal failure 435 alcoholic fatty liver 428 dementia 413 osteoporosis 397 hepatocellular carcinoma 397 hypercholesterolemia 389 liver disease 385 myocardial ischemia 375 DM2 373 heart disease 360 MODY 325 peripheral neuropathy 309 ischemia 303 breast cancer 302 plaque 286 chronic renal failure 261 diabetic ketoacidosis 246 obstructive sleep apnea 244 diabetic neuropathy 240 renal impairment 232 malnutrition 221 Evans 220 Parkinson's disease 218 essential hypertension 213 insulinoma 211 autonomic neuropathy 207 congestive heart failure 204 hepatitis C 195 rheumatoid arthritis 195 morbid obesity 190 sleep apnea 189 chronic liver disease 189 GSH 185 atherosclerotic cardiovascular disease 175 lactic acidosis 175 blindness 175 diabetic cardiomyopathy 173 schizophrenia 170 osteoarthritis 166 more...

Symptom overweight 1698 pain 356 nausea 201 fatigue 165 diarrhea 132 angina 126 vomiting 111 weakness 101 exhaustion 87 starvation 87 hunger 84 abdominal pain 81 polyuria 73 headache 70 polydipsia 67 discomfort 66 anesthesia 63 discomfort 49 anorexia 47 constipation 45 sleepiness 45 dizziness 44 dyspnea 44 seizures 41 cachexia 40 nausea and vomiting 40 cough 37 hepatomegaly 34 chest pain 33 insomnia 33 numbness 31 ketonuria 30 back pain 28 respiratory distress 26 myalgia 25 memory loss 25 thinning 24 Depressive symptoms 24 collapse 23 Ill 22 low back pain 21 functional recovery 21 hypothermia 21 stigma 20 Wind 18 arthralgia 17 hypotonia 16 paresthesia 16 snoring 15 shortness of breath 15 asthenia 13 erythema 13 decreased appetite 12 lethargy 12 menopausal symptoms 12 tingling 11 urinary frequency 11 hyperoxia 11 bloating 11 acute stress 11 analgesia 11 leg pain 9 Catch 9 hypercapnia 9 ataxia 9 splenomegaly 8 flushing 8 HSA 8 chills 8 thigh pain 7 syncope 7 tremor 7 tense 7 night sweats 6 agitation 6 acidity 6 apathy 6 hemoptysis 6 Decreased activity 6 Poor sleep 6 more...

Drug Cardiovasc 582 Glucagon 569 ADM 376 Liraglutide 205 Rosiglitazone 172 Exenatide 159 lysine 157 ROS 149 vitamin E 135 Monit 119 Troglitazone 103 niacin 98 ascorbate 98 caffeine 94 Angiotensin II 79 Gliclazide 73 Dermatol 72 ROC 68 Dial 58 Leaf 46 NADH 46 metformin hydrochloride 45 Fructose 45 AHF 44 IL-2 41 Orlistat 40 TAK 37 Bifidobacterium 37 Insulin glargine 35 Albumin 34 EPA 33 Nephron 32 Perindopril 30 Rimonabant 29 Pramlintide 29 Simvastatin 29 ALA 29 Ramipril 28 Glide 28 Insulin detemir 28 CPR 27 Vitamin E 26 MAP 25 Valsartan 25 Vitamin A 24 Growth hormone 24 lactose 23 Colesevelam 23 PTH 23 Nephron 22 Growth hormone 22 Spectrum 22 Lantus 21 Ethanol 21 DM1 21 Kenyan 20 Januvia 19 nitroglycerin 19 citric acid 19 CTX 19 CTX 18 CTX 18 Asn 18 CSF 17 Portal 17 Ginseng 17 ABC 17 Gel 16 Avandia 16 IL-1ra 15 Ezetimibe 15 Parkin 15 ACT 15 Parkin 15 Nitric Oxide 15 EE2 14 CAM 14 Fluorescein 13 Lovastatin 13 Insulin lispro 13 more...

Enzyme AMP-activated protein kinase 927 mitogen-activated protein kinase 647 renin 635 protein kinase 619 glucokinase 407 AMPK 387 AMPK 375 ACE 361 superoxide dismutase 360 alanine aminotransferase 283 ERK 268 protein kinase C 247 catalase 242 alpha-glucosidase 219 phosphoenolpyruvate carboxykinase 216 dipeptidyl peptidase IV 208 aspartate aminotransferase 201 focal adhesion kinase 176 phosphatidylinositol 3-kinase 171 lipoprotein lipase 165 phosphoenolpyruvate carboxykinase 163 phosphoenolpyruvate carboxykinase 161 luciferase 157 caspase-3 157 glutathione peroxidase 151 glucose-6-phosphatase 148 lipase 132 NADPH oxidase 126 alkaline phosphatase 118 GSK 117 ATPase 114 NADPH oxidase 99 gamma-glutamyl transpeptidase 92 acetyl-CoA carboxylase 92 ACS 87 complex I 86 proteasome 84 NO synthase 84 thrombin 82 aldehyde dehydrogenase 81 calcineurin 77 phosphoinositide 3-kinase 76 phosphodiesterase 75 AST 73 caspase-1 72 phosphorylase 70 peroxidase 70 lactate dehydrogenase 69 aldose reductase 66 tissue plasminogen activator 62 CPT 60 hexokinase 58 pyruvate dehydrogenase 54 insulin-degrading enzyme 53 hormone-sensitive lipase 51 IKK 51 adenylate cyclase 50 11beta-hydroxysteroid dehydrogenase 48 PDK1 47 reverse transcriptase 47 pyruvate dehydrogenase 46 CAD 46 pyruvate dehydrogenase 46 CAD 46 acetylcholinesterase 46 CAD 46 citrate synthase 45 creatine kinase 44 trypsin 44 paraoxonase 43 MEK 42 pyruvate kinase 42 CD10 40 LPL 40 paraoxonase 39 xanthine oxidase 37 glucose oxidase 36 calpain 10 36 glucose-6-phosphate dehydrogenase 36 phospholipase C 32 more...

Compound glucose 21525 Clin 5226 Dec 3916 Insulin 3103 oxygen 1423 DNA 1416 sodium 1274 creatinine 1110 Metformin 1077 Metformin 1065 calcium 976 Pac 930 water 874 DPP 822 ATP 749 Diabetol 688 Cardiol 657 TNF 600 Diabetol 593 Glucagon 569 MOD 552 nitric oxide 532 tyrosine 415 vitamin D 394 acetate 378 arginine 376 potassium 369 cAMP 342 serine 338 phosphate 333 Sodium 293 zinc 273 AMP 265 aldosterone 261 alanine 258 hydrogen 244 urea 230 STZ 227 palmitic acid 225 iron 224 lysine 222 Pioglitazone 217 galactose 212 leucine 210 silver 209 His 207 nitrogen 201 ethanol 201 nicotinamide 194 GSH 193 GSH 193 Cholesterol 191 Pima 188 salt 187 threonine 184 glycerol 178 NAD 155 homocysteine 152 ADP 150 palmitic acid 147 methionine 142 Angiotensin II 141 cysteine 135 sulfate 129 ADP 128 ADP 127 glutamate 126 NAD 125 CoA 120 Phe 119 chromium 115 copper 114 Vitamin D 111 glutamine 107 Optimal 106 selenium 106 Hemoglobin 102 proline 96 caffeine 94 retinol 94 more...

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