Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011860 (type 2 diabetes)
57,723 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 25338
Sep 3496
glucagon 3025
hemoglobin 2655
Mol 2358
NIDDM 2271
HDL 1466
adiponectin 1464
peptidase 1302
gut 1232
leptin 1205
GLP-1 receptor 1204
albumin 1095
insulin receptor 854
cytokine 828
DPP 822
C-reactive protein 781
ATP 749
amylin 742
GLP-1 727
peroxisome proliferator-activated receptor 684
renin 635
endoplasmic reticulum 624
IRS-1 611
TNF 600
peroxisome proliferator-activated receptor gamma 591
tumor necrosis factor 589
IDDM 581
AMP-activated protein kinase 577
IL-6 571
glucokinase 406
glucose transporter 390
GLUT4 384
AMPK 375
DM2 373
adipokine 369
sodium-glucose cotransporter 361
glucosidase 351
Adiponectin 345
interleukin-6 338
more...
Disease
type 2 diabetes 57723
diabetes 25264
obesity 13374
hypertension 5481
cardiovascular disease 5277
hyperglycemia 4664
metabolic syndrome 4303
type 1 diabetes 2930
glucose intolerance 2800
hypoglycemia 2448
dyslipidemia 2395
atherosclerosis 2361
cancer 2261
renal disease 1833
hyperinsulinemia 1518
diabetic nephropathy 1441
fatty liver 1277
stroke 1229
Alzheimer's disease 1130
coronary artery disease 1071
hyperlipidemia 1040
coronary heart disease 1028
heart failure 1000
retinopathy 903
myocardial infarction 853
gestational diabetes mellitus 845
prediabetes 786
diabetic retinopathy 712
microalbuminuria 710
depression 684
neuropathy 625
polycystic ovary syndrome 557
chronic disease 530
proteinuria 520
abdominal obesity 503
metabolic disorder 487
tumor 482
cirrhosis 478
vascular disease 459
Nonalcoholic fatty liver 457
more...
Symptom
overweight 1698
pain 356
nausea 201
fatigue 165
diarrhea 132
angina 126
vomiting 111
weakness 101
exhaustion 87
starvation 87
hunger 84
abdominal pain 81
polyuria 73
headache 70
polydipsia 67
discomfort 66
anesthesia 63
discomfort 49
anorexia 47
sleepiness 45
constipation 45
dyspnea 44
dizziness 44
seizures 41
nausea and vomiting 40
cachexia 40
cough 37
hepatomegaly 34
insomnia 33
chest pain 33
numbness 31
ketonuria 30
back pain 28
respiratory distress 26
myalgia 25
memory loss 25
Depressive symptoms 24
thinning 24
collapse 23
Ill 22
more...
Drug
Cardiovasc 582
Glucagon 569
ADM 376
Liraglutide 205
Rosiglitazone 172
Exenatide 159
lysine 157
ROS 149
vitamin E 135
Monit 119
Troglitazone 103
ascorbate 98
niacin 98
caffeine 94
Angiotensin II 79
Gliclazide 73
Dermatol 72
ROC 68
Dial 58
Leaf 46
NADH 46
metformin hydrochloride 45
Fructose 45
AHF 44
IL-2 41
Orlistat 40
Bifidobacterium 37
TAK 37
Insulin glargine 35
Albumin 34
EPA 33
Nephron 32
Perindopril 30
Rimonabant 29
Simvastatin 29
Pramlintide 29
ALA 29
Ramipril 28
Insulin detemir 28
Glide 28
more...
Enzyme
AMP-activated protein kinase 927
mitogen-activated protein kinase 647
renin 635
protein kinase 619
glucokinase 407
AMPK 387
AMPK 375
ACE 361
superoxide dismutase 360
alanine aminotransferase 283
ERK 268
protein kinase C 247
catalase 242
alpha-glucosidase 219
phosphoenolpyruvate carboxykinase 216
dipeptidyl peptidase IV 208
aspartate aminotransferase 201
focal adhesion kinase 176
phosphatidylinositol 3-kinase 171
lipoprotein lipase 165
phosphoenolpyruvate carboxykinase 163
phosphoenolpyruvate carboxykinase 161
caspase-3 157
luciferase 157
glutathione peroxidase 151
glucose-6-phosphatase 148
lipase 132
NADPH oxidase 126
alkaline phosphatase 118
GSK 117
ATPase 114
NADPH oxidase 99
gamma-glutamyl transpeptidase 92
acetyl-CoA carboxylase 92
ACS 87
complex I 86
proteasome 84
NO synthase 84
thrombin 82
aldehyde dehydrogenase 81
more...
Compound
glucose 21525
Clin 5226
Dec 3916
Insulin 3103
oxygen 1423
DNA 1416
sodium 1274
creatinine 1110
Metformin 1077
Metformin 1065
calcium 976
Pac 930
water 874
DPP 822
ATP 749
Diabetol 688
Cardiol 657
TNF 600
Diabetol 593
Glucagon 569
MOD 552
nitric oxide 532
tyrosine 415
vitamin D 394
acetate 378
arginine 376
potassium 369
cAMP 342
serine 338
phosphate 333
Sodium 293
zinc 273
AMP 265
aldosterone 261
alanine 258
hydrogen 244
urea 230
STZ 227
palmitic acid 225
iron 224
more...