Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011860 (
type 2 diabetes
)
57,723
document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
insulin
25338
Sep
3496
glucagon
3025
hemoglobin
2655
Mol
2358
NIDDM
2271
HDL
1466
adiponectin
1464
peptidase
1302
gut
1232
leptin
1205
GLP-1 receptor
1204
albumin
1095
insulin receptor
854
cytokine
828
DPP
822
C-reactive protein
781
ATP
749
amylin
742
GLP-1
727
peroxisome proliferator-activated receptor
684
renin
635
endoplasmic reticulum
624
IRS-1
611
TNF
600
peroxisome proliferator-activated receptor gamma
591
tumor necrosis factor
589
IDDM
581
AMP-activated protein kinase
577
IL-6
571
glucokinase
406
glucose transporter
390
GLUT4
384
AMPK
375
DM2
373
adipokine
369
sodium-glucose cotransporter
361
glucosidase
351
Adiponectin
345
interleukin-6
338
more...
Disease
type 2 diabetes
57723
diabetes
25264
obesity
13374
hypertension
5481
cardiovascular disease
5277
hyperglycemia
4664
metabolic syndrome
4303
type 1 diabetes
2930
glucose intolerance
2800
hypoglycemia
2448
dyslipidemia
2395
atherosclerosis
2361
cancer
2261
renal disease
1833
hyperinsulinemia
1518
diabetic nephropathy
1441
fatty liver
1277
stroke
1229
Alzheimer's disease
1130
coronary artery disease
1071
hyperlipidemia
1040
coronary heart disease
1028
heart failure
1000
retinopathy
903
myocardial infarction
853
gestational diabetes mellitus
845
prediabetes
786
diabetic retinopathy
712
microalbuminuria
710
depression
684
neuropathy
625
polycystic ovary syndrome
557
chronic disease
530
proteinuria
520
abdominal obesity
503
metabolic disorder
487
tumor
482
cirrhosis
478
vascular disease
459
Nonalcoholic fatty liver
457
more...
Symptom
overweight
1698
pain
356
nausea
201
fatigue
165
diarrhea
132
angina
126
vomiting
111
weakness
101
exhaustion
87
starvation
87
hunger
84
abdominal pain
81
polyuria
73
headache
70
polydipsia
67
discomfort
66
anesthesia
63
discomfort
49
anorexia
47
sleepiness
45
constipation
45
dyspnea
44
dizziness
44
seizures
41
nausea and vomiting
40
cachexia
40
cough
37
hepatomegaly
34
insomnia
33
chest pain
33
numbness
31
ketonuria
30
back pain
28
respiratory distress
26
myalgia
25
memory loss
25
Depressive symptoms
24
thinning
24
collapse
23
Ill
22
more...
Drug
Cardiovasc
582
Glucagon
569
ADM
376
Liraglutide
205
Rosiglitazone
172
Exenatide
159
lysine
157
ROS
149
vitamin E
135
Monit
119
Troglitazone
103
ascorbate
98
niacin
98
caffeine
94
Angiotensin II
79
Gliclazide
73
Dermatol
72
ROC
68
Dial
58
Leaf
46
NADH
46
metformin hydrochloride
45
Fructose
45
AHF
44
IL-2
41
Orlistat
40
Bifidobacterium
37
TAK
37
Insulin glargine
35
Albumin
34
EPA
33
Nephron
32
Perindopril
30
Rimonabant
29
Simvastatin
29
Pramlintide
29
ALA
29
Ramipril
28
Insulin detemir
28
Glide
28
more...
Enzyme
AMP-activated protein kinase
927
mitogen-activated protein kinase
647
renin
635
protein kinase
619
glucokinase
407
AMPK
387
AMPK
375
ACE
361
superoxide dismutase
360
alanine aminotransferase
283
ERK
268
protein kinase C
247
catalase
242
alpha-glucosidase
219
phosphoenolpyruvate carboxykinase
216
dipeptidyl peptidase IV
208
aspartate aminotransferase
201
focal adhesion kinase
176
phosphatidylinositol 3-kinase
171
lipoprotein lipase
165
phosphoenolpyruvate carboxykinase
163
phosphoenolpyruvate carboxykinase
161
caspase-3
157
luciferase
157
glutathione peroxidase
151
glucose-6-phosphatase
148
lipase
132
NADPH oxidase
126
alkaline phosphatase
118
GSK
117
ATPase
114
NADPH oxidase
99
gamma-glutamyl transpeptidase
92
acetyl-CoA carboxylase
92
ACS
87
complex I
86
proteasome
84
NO synthase
84
thrombin
82
aldehyde dehydrogenase
81
more...
Compound
glucose
21525
Clin
5226
Dec
3916
Insulin
3103
oxygen
1423
DNA
1416
sodium
1274
creatinine
1110
Metformin
1077
Metformin
1065
calcium
976
Pac
930
water
874
DPP
822
ATP
749
Diabetol
688
Cardiol
657
TNF
600
Diabetol
593
Glucagon
569
MOD
552
nitric oxide
532
tyrosine
415
vitamin D
394
acetate
378
arginine
376
potassium
369
cAMP
342
serine
338
phosphate
333
Sodium
293
zinc
273
AMP
265
aldosterone
261
alanine
258
hydrogen
244
urea
230
STZ
227
palmitic acid
225
iron
224
more...