Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been proposed that type 1 and 2 diabetes might share common pathophysiological pathways and, to some extent, genetic background. However, to date there has been no convincing data to establish a molecular genetic link between them. We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2). We were unable to confirm a recently published association of the IRS1 Gly972Arg variant with type 1 diabetes. Moreover, KCNJ11 Glu23Lys showed no association with type 1 diabetes (P > 0.05). However, the PPARG2 Pro12Ala variant showed evidence of association (RR 1.15, 95% CI 1.04-1.28, P = 0.008). Additional studies need to be conducted to confirm this result.
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PMID:Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. 1498 78

Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene polymorphism has been indicated as relevant to type 2 diabetes mellitus (T2D) susceptibility, but research results remain debatable.To investigate the relationship between KCNJ11 E23K gene polymorphism and T2D in the Chinese Han population, a meta-analysis involving 3,080 T2D patients and 3,029 controls from five separate studies was conducted. The pooled odds ratio (ORs) for the association between KCNJ11 E23K gene polymorphism and T2D and its corresponding 95 % confidence interval (95 % CI) were estimated using a random effects model.A significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the pooled Chinese Han population through an allelic genetic model (OR: 1.21, 95 % CI: 1.04-1.40, P = 0.01) and a recessive genetic model (OR: 1.44, 95 % CI: 1.25-1.65, P < 0.00001). In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41-1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population.
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PMID:The KCNJ11 E23K gene polymorphism and type 2 diabetes mellitus in the Chinese Han population: a meta-analysis of 6,109 subjects. 2305 5