Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study the relationship of the concentration of serum lipoprotein (a) [Lp(a)] with diabetic complications in non-insulin dependent diabetes mellitus (NIDDM), 100 non-diabetics with 150 patients with NIDDM were compared. There was no difference in Lp(a) concentration (P > 0.5) between the two groups. Lp(a) concentration was not significantly correlated with the levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, apolipoprotein A-I, apolipoprotein B in both groups. In NIDDM group, patients with hypertension, macro- and microangiopathy had higher levels of Lp(a) than those without these complications (P < 0.001 and P = 0.002 respectively). Lp(a) level was positively related to presence of macroangiopathy (r = 0.185, P = 0.024) and proteinuria (r = 0.316, P < 0.001) in NIDDM.
Zhonghua Nei Ke Za Zhi 1996 Apr
PMID:[Lipoprotein (a) and non-insulin dependent diabetes mellitus]. 938 40

In order to evaluate insulin sensitivity and its related factors in abnormal glucose tolerance, 572 cases of non-insulin dependent diabetes mellitus (NIDDM), 647 cases of impaired glucose tolerance (IGT) and 543 normal controls were studied. The results showed that fasting insulin levels (FIns) and the prevalence of hyperinsulinemia were higher in NIDDM than that in IGT and higher in IGT than that in normal controls (P < 0.01). Insulin sensitivity index (ISI) [-ln(FInx x fasting blood glucose)] ranked from high to low in the order of normal controls, IGT subjects, newly-diagnosed NIDDM patients and patients with known NIDDM (P < 0.01). In each group ISI was smaller in obese subjects or patients than in non-obese ones. Mono-factor analysis demonstrated that ISI in each group was negatively related to body mass index (BMI) and positively related to high density lipoprotein (HDL)-cholesterol. ISI in NIDDM and IGT group was negatively related to blood pressure. Multiple analysis showed that the ISI had significantly negative correlation with BMI and some correlation with blood pressure and blood lipids. In conclusion, the patients with abnormal glucose tolerance had hyperinsulinemia and insulin resistance. ISI was related to some risk factors of vascular diseases.
Zhonghua Nei Ke Za Zhi 1996 Oct
PMID:[A study of insulin sensitivity and its related factors in patients with non-insulin dependent diabetes mellitus and impaired glucose tolerance]. 959 28

Fourty six cases of non-insulin dependent diabetes mellitus (NIDDM) with normotension and microalbuminuria (< 30 mg/24 h) were divided into groups A and B, and observed for about 2 years. Only group A was treated with perindopril 2 mg a day. We found that 2 years later glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and filtration fraction (FF) in the two groups decreased markedly, but GFR and FF decreased more markedly in group B than in group A. Meanwhile, in group A urinary albumin excretion rate (UAER) and insulin sensitivity index (SI) decreased significantly and blood pressure was stable, but in group B UAER and blood pressure elevated significantly and SI was only slightly ameliorated (P > 0.05). The levels of serum triglycerides and cholesterol were not markedly different between the two groups during the 2 years. These results indicate that ACEI may play a role in protecting the renal function in diabetic nephropathy, reduce the risk factors of atherosclerosis and improve SI. It is beneficial to retard the development of diabetic nephropathy and to protect in renal function with small dose of ACEI.
Zhonghua Nei Ke Za Zhi 1996 Aug
PMID:[Protective effect of angiotensin coverting enzyme inhibitor on renal function in normotensive non-insulin dependent diabetes mellitus patients with early diabetic nephropathy and microalbuminuria]. 959 45

We studied the prevalence of diabetes and impaired glucose tolerance (IGT) and their risk factors in the population of China. It was a population-based, cross-sectional study of 224,251 residents aged 25 years and over in 19 provinces and areas, including cities and rural areas of the North, South, East, West and central China. Using 1985 WHO criteria, We found the prevalence of diabetes and IGT were 2.51% and 3.20% respectively in 213,515 subjects aged 25 to 64 years. 70.33% of the subjects had newly recognised diabetes. The prevalence of diabetes in China is about 3 times higher than it was ten years ago, and the rate is increasing faster in the countryside than in cities. On average, subjects with diabetes are older, have higher personal annual incomes, and have more frequently a family history of diabetes. They also have higher mean body mass index (BMI), ratio of circumference of the waist to hip, systolic blood pressure, diastolic blood pressure and a greater prevalence of hypertension. They perform less physical activity and receive less education than persons with normal OGTT. Multiple logistic, stepwise regression analysis shows that age, BMI (or WHR), family history of diabetes, hypertension, less physical activity and higher annual income are independent risk factors of NIDDM, and that low education is also an independent risk factor of NIDDM in people with higher personal annual income.
Zhonghua Nei Ke Za Zhi 1997 Jun
PMID:[Prevalence of diabetes and its risk factors in China 1994. National Diabetes Prevention and Control Cooperative Group]. 1037 97

To understand latent autoimmune diabetes mellitus in adults (LADA), we compared the clinical characteristics, fasting plasma glucose and C-peptide level, genetic frequency of HLA-DQA1, -DQB1 chain in 25 patients with LADA, 57 patients with insulin-dependent diabetes mellitus (IDDM, 21 patients with children-onset IDDM, 36 patients with adult-onset IDDM with ketosis), 38 patients with NIDDM (mild and moderate 30 patients and severe 8) and 42 normal persons. The onset of age was 20-48 years old associated with obvious polyphagia, and weight loss. Body mass index (BMI) was < or = 25 and fasting plasma glucose was > or = 16.5 mmol/L (297 mg/dl). Fasting and 1, 2 hour post prandial C-peptide level showed low and flatter curve (0.4, 0.8 and 0.8 nmol/L respectively). Glutamate decarboxylase (GAD) antibody was positive. HLA-DQ beta chain substitution of aspartate molecule was at position 57 (susceptic gene). LADA could be diagnosed if a patient has the first point and any point of the second to the fourth point. Patients with LADA should take diet, exercises, especially insulin as early as possible in order to control fasting and post prandial plasma glucose, and prevent from further destroy of residue islet B cells and reduce diabetic complications of eye, kidney and nerve.
Zhonghua Nei Ke Za Zhi 1997 Mar
PMID:[Clinical characteristics and main diagnostic points of latent autoimmune diabetes mellitus in adults]. 1037 7

We described the clinical significance of the measurement of insulin receptors and the mechanism of non-insulin dependent diabetes mellitus (NIDDM). Changes in insulin receptor (IR) of red blood cells in 47 patients with NIDDM were compared with those of 28 normal controls. The levels of high and low-affinity IR in the 47 patients with NIDDM were lower than those of normal controls and were prominent in untreated new NIDDM patients. Hyperinsulinemia was not found in these patients, indicating that the low IR is a primary defect not caused by the "down regulation" mechanism. In the IDDM patients the levels of high and low-affinity IR were higher than those of the normal controls, but decreased markedly after insulin therapy, indicating that the "up regulation" is attributable to the high IR levels, other than the primary IR defect.
Zhonghua Nei Ke Za Zhi 1997 Sep
PMID:[Insulin receptors in diabetes mellitus]. 1043 71

This study was conducted to evaluate the relationship between serum insulin levels and the production of insulin antibody (IA) in type 2 diabetes (T2DM). A total of 647 T2DM were included. Among them, 20.9% patients were IA positive, who were elder and had a longer duration, lower BMI, a higher positive rate of glutamic acid decarboxylase antibody(GADAb) and higher serum insulin levels during an insulin secretion test. More patients were treated with insulin in IA positive group than in IA negative group (65.9% vs 41.0%, P=0.000). Fasting serum insulin level was associated with occurrence of IA in all patients (OR=1.02, P=0.001) and insulin treated patients (OR=1.033, P=0.002). The cut-off point of fasting serum insulin level for predicting IA positive was 17.87 mIU/L (sensitivity 55.1%, specificity 89.0%). Exogenous insulin use is associated with the presence of IA. Fasting serum insulin level can be used as a predictor for the production of IA in insulin-treated patients.
Zhonghua Nei Ke Za Zhi 2016 Jul 01
PMID:[A clinical analysis of insulin antibody in type 2 diabetic patients]. 2737 91


<< Previous 1 2