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Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Basal serum growth hormone and response of GH to GRF in 10 patients with noninsulin-dependent diabetes and in 10 control subjects were studied. The basal GH level in NIDDM was higher than that in control subjects. There was a significant difference. After an intravenous bolus of hGRF 1-29 NH2 with the dose of 1 microgram/kg body weight, GH (Peak level-basal level) decreased in NIDDM patients in comparing with control group (P < 0.05). These findings may suggest that the pituitary GH reserve is reduced in patients with NIDDM. There exists some defect in central GH control in diabetics with enhanced somatostatin secretion and abnormal sensitivity of the GH secretion cells to a variety of regulatory factors including GRF, glucose, amino-acids, free fat acid.
Zhonghua Nei Ke Za Zhi 1992 Dec
PMID:[Blunted growth hormone response to hGRF 1-29 NH2 in patients with non-insulin-dependent diabetes mellitus]. 130 83

This study enrolled 36 newly-diagnosed patients with NIDDM, who were divided into two groups, the glibenclamide group and the glipizide group. In each group there were 18 cases, and both group were equal in average age and duration, steam bread tolerance test, GHbA1 and 6 hematological targets were made in both groups before and after administration with glibenclamide or glipizide. The results were as follows: (1) The hypoglycemic effect of glibenclamide was slightly great than that of glipizide. (2) VWF decreased significantly after administration with glibenclamide for 4 months. But in glipizide, only the length of thrombosis formation in vitro was greatly shortened. Thus glibenclamide was better than glipizide, in postponing and reducing microangiopathy complication.
Zhonghua Nei Ke Za Zhi 1991 Feb
PMID:[A comparison between glibenclamide and glipizide in the treatment of type II diabetes]. 190 39

The widespread and depth-in investigations on the pulmonary change in DM have been documented abroad. Some revealed that the abnormalities of pulmonary function usually exist in DM. There has been no similar report found in China so far. In this study, ventilation, small airway function (V25 and V50), diffusion capacity and artery blood gas studies have been done in 60 DM and 62 healthy subjects respectively. The results have shown that there is a significant difference between NIDDM group and control group (P less than 0.05) in V50, V25, DLCO and the reduced value of PaO2, and there exists remarkably significant difference between the IDDM group and control group (P less than 0.01) in the decreased values of TLC, FEV1.0%, V50, V25, DLCO, PaCO2 and PaO2.
Zhonghua Nei Ke Za Zhi 1990 Dec
PMID:[Pulmonary function and artery blood analysis of diabetes mellitus]. 209 57

Although oral glucose tolerance test (OGTT) has been the key examination in early diagnosis of diabetes mellitus, but it still has some problems. It may be affected by some physiological or pathological changes and also requires frequent blood sampling. We investigated the usefulness of measuring the level of glycated hemoglobin (GHb) or HbA1 and HbA1c in screening or early diagnosis of diabetes mellitus. OGTT was performed and fasting levels of HbA1 and HbA1c were measured in 168 subjects. According to the diagnostic criteria of WHO for 75g OGTT, 31 subjects were classified as normal, 35 as having impaired glucose tolerance test (IGT) and 102 as diabetics. The method used for determination of HbA1 and HbA1c was high pressure liquid chromatography (HPLC). The total discovery rate for GHb in diabetic patients was 87%. In patients with fasting level of plasma glucose (FPG) greater than or equal to 8 mmol/L the discovery rate was 100%, while in those with level of FPG less than or equal to 7.94 mmol/L the rate was 80%. Thus, GHb is very useful in screening and early diagnosis of NIDDM (type II), especially diabetes mellitus of the elderly.
Zhonghua Nei Ke Za Zhi 1989 Jul
PMID:[Evaluation of glycated hemoglobin in the early diagnosis of diabetes mellitus]. 259 Dec 59

The effectiveness of combined therapy with insulin and sulfonylurea in non-insulin dependent diabetes mellitus (NIDDM) patients has, for decades, been a debated issue. In order to probe this question, we studied 33 diabetes mellitus patients aged 40 years and over, having a history of this disease for more than 5 years, treated with one of the sulfonylureas at maximal dosage for three weeks but without effect. These 33 cases were divided into three groups randomly: group A: treated with glurenorm and insulin. B insulin and C glurenorm. The treatment lasted 4 months. During the course of the trial, estimation of the free-insulin, C-peptide, blood glucose etc. was carried out three times i.e. one before the trial and then 2, 4 months after the trial. The data were dealed with U-test and comparison was made before and after the trial and between the three groups. It is shown that combined therapy with sulfonylurea and insulin is effective in NIDDM patients, especially in those with secondary failure of beta-cell function and the combined therapy may be used in NIDDM patients during the transitional period from treatment with sulfonylurea alone to traditional insulin cure.
Zhonghua Nei Ke Za Zhi 1995 Apr
PMID:[The effectiveness of combined insulin and sulfonylurea in treating non-insulin dependent diabetic patients]. 758 4

The effect of essential hypertension at baseline on the development of NIDDM within 6 years was investigated in 465 Chinese nondiabetics with or without hypertension. The age, sex adjusted 6 year incidence of NIDDM in hypertensive group (BP > 18.7 +/- 12. okPa (140/90 mmHg) or treated with antihypertensives) at baseline was significantly higher than that in normotensive group (44.6%, n = 325, P < 0.05) at baseline. Multivariate regression analysis showed the hypertensive group had higher risk of worsening to diabetes compared with normotensives (OR: 1.82, 95% Ci: 1.03-3.21, P < 0.05) after the adjustment for two other important risk factors for NIDDM, the fasting plasma glucose and BMI. Further more the increasement of SBP by 20 mmHg at baseline significantly increase the risk for NIDDM in the followup period in the blood-lowering-drug-free group (OR: 1.54, 95% Ci: 1.05-2.24, P < 0.05). Thus it confirmed that hypertension at baseline was an independent predictor for NIDDM. In addition, our observation showed that some antihypertensive drugs appears also to play an unfavorable role in the occurrence of NIDDM.
Zhonghua Nei Ke Za Zhi 1994 Oct
PMID:[Essential hypertension: a predictor of the 6 year-incidence of NIDDM in 465 non-diabetics]. 771 8

Plasma levels of endothelin (ET), vasoconstrictor peptide released from vascular endothelial cells, have been measured by radioimmunoassay in 48 patients with NIDDM and 20 healthy subjects. The plasma ET concentrations were found to be greatly elevated in the patients with diabetes compared with the healthy subjects (P < 0.001). We also find that the plasma levels of ET were higher in diabetic patients with complication of diabetes mellitus than in those without complication (P < 0.02). The elevated ET levels were related to hypertension and/or diabetic angiopathy. There were no significant correlations between plasma ET concentrations and blood glucose, HbA1 et al. In diabetic patients elevated ET levels may play a pathophysiological role in the development of diabetic complication.
Zhonghua Nei Ke Za Zhi 1994 Jul
PMID:[The relationship between the plasma levels of endothelin and angiopathy in diabetic patients]. 786 43

A14-125I-monoiodoinsulin binding to, internalization into, and degradation inside human circulating monocytes, a cell type widely used for insulin receptor studied, from normal(32) and weight, age-matched NIDDM(31) subject were studied. The specific insulin binding, internalization and degradation were decreased in the cells from NIDDM compared to that in the cells from normal subjects. Scatchard plot analysis of these group data reveal that cells from the normal control subject contain 28,000 receptor sites per cell, while monocytes from the NIDDM patients contain 15,000 sites per cell. These results indicate that the decreased abilities of insulin binding, internalization and degradation of target cells may play a role in the cellular resistance to insulin that occurs in the NIDDM.
Zhonghua Nei Ke Za Zhi 1993 Dec
PMID:[Defects in insulin binding, internalization and degradation of monocytes from patients with non-insulin-dependent diabetes mellitus]. 803 59

Autoimmune mechanisms may be involved in the pathogenesis of insulin dependent diabetes mellitus (IDDM). Multiple autoantibodies have been detected in patients with IDDM. Islet cell antibodies (ICA), complent-fixing islet cell antibodies (CF-ICA) and antibodies to an islet cell protein 64000 M(r) (64K antibodies) have been regarded as immunological markers in IDDM. ICA detection with immunohistochemistry requires fresh normal human pancreas (blood group O) which provides an antigen for measuring ICA in serum samples. In the present study ICA detection was first carried out by using avidin-biotin-peroxidase complex technique (ABC) method and paraffin sections of human pancreas (blood group O), Serum samples were obtained from 17 patients with IDDM, 20 with NIDDM and 20 without diabetes mellitus. In patients with IDDM, ICA were detected in 9 of the 17 (52.94%) while none of the patients with NIDDM and without diabetes mellitus were ICA positive. In comparison with other methods, the present one is more reliable, sensitive, specific and simple. Therefore, it may be widely used for ICA detection in clinical practice.
Zhonghua Nei Ke Za Zhi 1994 Feb
PMID:[Detection of islet cell antibodies by using avidin-biotin-peroxidase complex technique]. 807 Feb 98

Based on the survey of the prevalence of NIDDM in 110 660 people aged 25-74 in 1986, the incidence of NIDDM was investigated in 1990 in 36 471 people (M/F 18,801:17,670) who had normal glucose tolerance and/or plasma glucose concentration less than 6.7 mmol/L 2-hour after breakfast (carbohydrate 80 g) four years ago in Daqing, Heilongjiang province, northeast China. 103 male and 88 female diabetics were diagnosed among the 36 471 subjects from June 1986 to June 1990. This result showed that the annual incidence of NIDDM in this area is 131/100,000 (137 in males, 125 in females), and is 130/100,000 standardized to the 1982's chinese population (95% confidence interval, 94-168/100,000). We may estimate that there would be 754 thousand new diabetics per year in 25-74 years old Chinese if the total population were 1.3 billion in China in the 21st century.
Zhonghua Nei Ke Za Zhi 1993 Mar
PMID:[Incidence of NIDDM in Daqing and forecasting of NIDDM in China in 21st century]. 822 82


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