Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Zn/Cu ratio was examined in the serum of three groups of persons: healthy volunteers, diabetic patients on diabetic diet (NIDDM), and diabetic patients on diabetic diet and insulin (IDDM). Zinc, copper, the Zn/Cu serum ratio, and the blood glucose level were determined during fasting and 2 h after breakfast. Zn and Cu serum levels in NIDDM and IDDM patients were decreased. The Zn/Cu ratio was higher in both groups of diabetic patients. These changes in the Zn and Cu levels as well as in the Zn/Cu ratio were not related to chronic diabetic complications.
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PMID:Zinc and copper in the serum of diabetic patients. 137 73

Zinc is known to have important effects on insulin activity, to increase the body fat deposition, and thyroid hormones conversion (T4 to T3). It is also known to have intestinal absorption competition between zinc and copper. This study was to investigate the blood zinc and copper concentrations in NIDDM and obesity, the relationships among metals, insulin, and thyroid hormones were also determined. Blood samples of diabetic, obese, and healthy individuals were collected between 9-10 AM, and the blood levels of zinc, copper, insulin, T4 and T3 were assayed. The results showed that diabetics and obese individuals had higher insulin and T3 levels than healthy controls, but there was no difference in T4. The obese had lower serum zinc concentration. There were low levels of copper both in serum and erythrocyte, and a low erythrocyte zinc concentration in NIDDM. Blood zinc concentration was inversely related to T3 level in diabetics and obese individuals. It is suggested that zinc, insulin and T3 may have considerable correlations in the thermoregulation on NIDDM and obesity, and the true mechanisms still need more further studies in the future.
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PMID:[Investigation on the relationships among blood zinc, copper, insulin and thyroid hormones in non-insulin dependent diabetes mellitus and obesity]. 166 81

The ingestion of fructose, particularly in refined form, has significantly increased in the North American diet over the last two decades. The unique way in which fructose is metabolized has given rise to much research examining whether fructose is advantageous in appetite control, exercise endurance, and disease states such as diabetes. Overall, there is very little evidence that modest amounts of fructose have detrimental effects on carbohydrate and lipid metabolism in nondiabetic or NIDDM subjects or that its use is particularly advantageous compared to that of other sugars. However, fructose can cause insulin and triglyceride levels to rise dramatically, and hence be potentially harmful, in a subgroup of NIDDM subjects who have concomitant pronounced hypertriglyceridemia. Large doses of fructose should also be avoided by subjects with gout because of the hyperuricemia which may result. No evidence exists that fructose has any clear advantages over glucose in regard to exercise endurance. Similarly there is no conclusive evidence that physiologic amounts of dietary fructose exacerbate copper deficiency or aid in weight control.
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PMID:Current issues in fructose metabolism. 189 98

MOD cavity preparations in 64 endodontically treated premolars were restored using four different methods. Copper rings were filled with commercial hard-setting cement and the teeth were placed into the cement up to the level of the cementoenamel junction. The teeth were grouped according to restorative method, mounted in an Instrom T.T. machine, and the buccal walls subjected to a slowly increasing compressive force until fracture occurred. The force of fracture of the walls of each tooth was recorded and the results in the various groups compared. All teeth fractured in a similar manner irrespective of the restorative method used. The resistance to fracture of the teeth was the same when they were restored with glass ionomer cement as a base over which an amalgam or composite resin was placed or with acid-etched resin. When the entire cavities were filled with glass ionomer cement the resistance to fracture of the teeth decreased significantly compared with the acid etch resin technique.
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PMID:Resistance to fracture of endodontically treated premolars restored with glass ionomer cement or acid etch composite resin. 194 Jul 49

The authors studied linear alterations processed on copper-aluminum casten MOD blocks, obtained from two expansion techniques (termic and hygroscopic by immersion). UNITERMS: Investment expansion. Thermic expansion. Hygroscopic expansion. Casten Technique.
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PMID:[Linear changes in the cervical region of M.O.D. blocks cast in copper aluminum alloy with hygroscopic expansion and thermic techniques]. 212 65

The spontaneous diabetic Cohen-rat is one of the few animal models of the diabetes mellitus Type II (NIDDM). A spontaneous diabetic animal line and a diabetes-resistant line originated from a parental lineage by genetic selection with regard to the glucose tolerance on condition of feeding of a saccharose-rich and copper-poor diet. In each case 1000 islets of the diabetes-resistant line were transplanted in 28 animals of the diabetic line. Body weight, blood-sugar concentration, glucosuria, glucose tolerance, and the HbA1 were normalized after the transplantation. The serum levels of insulin and glucagon increased. These results emphasize etiopathogenetic importance of the islets of Langerhans in this animal model.
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PMID:[Islet transplantation in type II diabetes mellitus--model of the spontaneous diabetic Cohen rat]. 250 51

The majority of zinc, copper and magnesium is either intracellular or associated with the bones. It is therefore unlikely that the plasma concentration of these trace elements will reflect their whole body content. Blood cells might be more representative of lean tissue and are also easy to obtain. The concentration of zinc, copper and magnesium was measured in the leukocytes and hemoglobin of 42 subjects with non insulin dependent diabetes mellitus (NIDDM) and in 22 subjects with insulin dependent diabetes mellitus (IDDM) and was compared with that of 44 age-matched healthy volunteers. Zinc was found to be deficient in the serum (p less than 0.001), leukocyte (p less than 0.001) and hemoglobin (p less than 0.05) of the IDDM subjects, while copper and magnesium were increased in the serum, leukocytes and hemoglobin of the IDDM subjects (p less than 0.001). There was no zinc deficiency in the leukocytes of NIDD subjects. These results are opposite to the findings on zinc concentration in various tissue of animal models for IDDM and NIDDM and with our present knowledge on zinc status in IDDM and NIDDM subjects. Thus, we conclude that the concentration of zinc in blood cells of diabetic subjects might not reflect its concentration in various tissues.
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PMID:Trace elements in blood cells of diabetic subjects. 275 38

This study investigated the effect of polymerization shrinkage of posterior composite (Herculite) on the dimensions and fracture strength of human maxillary premolars with a phosphonate-ester DBA (Bondlite) and a second DBA comprised of 4-META with MMA/TBB (Superbond). The individual role of etched enamel and nonetched dentin bonding was also studied with high-copper amalgam used as a control. Two sizes of preparation isthmus were designated for evaluation of the effect of the polymerization contraction on weakened teeth. The following conclusions were drawn. 1. Narrow intracoronal tooth preparations were significantly stronger than wider, expansive preparations. There was no difference among the narrow isthmus preparations restored with amalgam or acid etching and composite. 2. There was a significant expansion in tooth dimension when MOD cavities were restored with amalgam. 3. Teeth with narrow isthmus preparations using composite bonded with Bondlite adhesive to etched enamel demonstrated a significant contraction compared with Superbond DBA. 4. Composite restorations using Superbond DBA in wide MOD cavities significantly improved the fracture strength of maxillary premolars. 5. Superbond DBA with composite restorations benefited the tooth in dimensional change and fracture strength. 6. There was a positive correlation between the fracture strength and tooth dimension.
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PMID:Cuspal deformation and fracture resistance of teeth with dentin adhesives and composites. 305 37

MOD cavities in 60 endodontically treated teeth were restored using six different methods. Copper rings were filled with commercial hard-setting cement and the teeth were placed up to the level of the cemento-enamel junction. The teeth were grouped according to restorative method, mounted in an Instron TT machine, and the buccal walls subjected to a slowly increasing compressive force until fracture occurred. The force of fracture of the walls of each tooth was recorded and the results in the various groups compared. All teeth fractured in a similar manner irrespective of the restorative method used. All groups restored with the newer bonding system had higher resistance to fracture than those restored with an acid etch chemically cured composite resin technique. The groups restored with Den-Mat Tenure Core Paste or a Variglass VLC base and Prisma APH were significantly stronger than the acid etch Concise restored teeth (P < 0.05). No statistically significant differences were found between the other groups (P > 0.05).
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PMID:Resistance to fracture of endodontically treated premolars restored with new generation dentine bonding systems. 775 Oct 59

The aim of the present study was to analyze the frequency and the severity of cuspal fracture for posterior teeth endodontically treated by 91 Danish dentists and restored with amalgam either before 1975 or after 1979. A database from a previous study was analyzed (1584 teeth with an MO, a DO, or an MOD amalgam restoration without cuspal overlays). Teeth restored before 1975 had a significantly lower frequency of cusp fracture than teeth restored after 1979. Moreover, when comparing the frequency of subcrestal fractures, that of the second group (after 1979) was more than twice as high as that of the first group (before 1975). Two factors with a bearing on these findings changed in the time period 1975-1979; the high-copper amalgams took over in Denmark, and the use of Gates-Glidden burs to achieve straight-line access to the root canal was introduced. It is suggested that the weakening of the coronal part of the root, caused by the use of Gates-Glidden burs, and the expansion and low creep of high-copper amalgams may be two of the reasons for the increased frequency and severity of cuspal fracture found in the past decade in Denmark.
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PMID:Cusp fracture of endodontically treated posterior teeth restored with amalgam. Teeth restored in Denmark before 1975 versus after 1979. 849 64


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