Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011860 (
type 2 diabetes
)
57,723
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated the correlation between
type 2 diabetes
(T2D)-related genes and the clinical characteristics of T2D in the Chinese Han population. Our study included 319 patients and 387 controls. Age, gender, clinical features, medications intake and biochemical blood profiles were analyzed. Genotyping was performed on a total of 18 single nucleotide polymorphisms previously reported to be associated with T2D. Our analyses revealed that the CT genotype of
ARHGAP22
rs4838605 is associated with T2D risk. Upon analyzing the subjects' clinical characteristics, we found that for rs2811893, the TT genotype correlated with high creatinine levels, while the AA genotype of rs17045754 and the TT genotype of rs4838605 correlated with elevated triglyceride levels. In addition, the AA genotype of rs17376456 and the TT genotype of rs6214 (p = 0.006) correlated with elevated hemoglobin A1c levels. Lastly, those carrying the TT genotype of rs7772697 and the CA genotype of rs3918227 exhibited higher mean body mass index and Cystatin C than controls. Our results showing that the
ARHGAP22
gene is associated with an increased risk of T2D, and that seven SNPs in MYSM1, PLXDC2,
ARHGAP22
and HS6ST3 promote T2D progression and could help predict the clinical course of T2D in patients at risk.
...
PMID:Impact of diabetes-related gene polymorphisms on the clinical characteristics of type 2 diabetes Chinese Han population. 2786 28
Diabetic retinopathy (DR) is a common microvascular complication of diabetes. Circulating endothelial progenitor cells (EPCs) are derived from bone marrow and are characterized by pathological retinal neovascularization.
Rho GTPase Activating Protein 22
(
ARHGAP22
) is a DR susceptibility gene that interacts with its downstream regulatory protein ras-related C3 botulinum toxin substrate 1 (Rac1), to assist in endothelial cell angiogenesis and increasing capillary permeability. The aim of this study was to elucidate the relationship between
ARHGAP22
expression and EPC levels in
type 2 diabetes
(T2D) patients with DR. Fifty T2D patients with DR were recruited. Circulating EPCs were characterized as CD31
+
/vascular endothelial growth factor-2
+
/CD45
dim
/CD133
+
and were quantified using triple staining flow cytometry. Real-time polymerase chain reaction tests were used to quantify
ARHGAP22
expression. We found that T2D patients with proliferative DR had significantly lower EPC levels than those with non-proliferative DR (
P
= 0.028). T2D patients with EPC levels above the median value (> 4 cells/10
5
events) had higher levels of
ARHGAP22
expression (
P
= 0.002). EPC levels were positively correlated with
ARHGAP22
expression (
r
= 0.364,
P
= 0.009). Among T2D patients with DR, a higher expression of
ARHGAP22
was associated with higher levels of EPCs.
ARHGAP22
may be involved in the mobilization or active circulation of EPCs, thus contributing to neovascularization during DR development.
...
PMID:High levels of circulating endothelial progenitor cells in patients with diabetic retinopathy are positively associated with ARHGAP22 expression. 2970 51
