Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011860 (
type 2 diabetes
)
57,723
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Using the data of 131 patients with
non-insulin dependent diabetes mellitus
(
NIDDM
), the correction formulas of fructosamine value ([
FRA
]) were devised to standardize the uncorrected [
FRA
] to serum albumin concentrations ([ALB]) of 4 g/dl, globulin concentrations ([GLB]) of 3 g/dl, and total protein concentrations ([TP]) of 7 g/dl. The following formula was derived for its maximum correlation coefficient (r) between corrected [
FRA
] ([FRAc]) and fasting blood glucose concentration ([G]); [FRAc] = [
FRA
]x33.3/(7.6 [ALB]+[GLB]). In these 131 diabetic patients, r between uncorrected [
FRA
] and [G] at 2 weeks ago was 0.562. When corrected by [
FRA
]x33.3/(7.6 [ALB]+[GLB]), [
FRA
]x4/[ALB], [
FRA
]+30 (4-[ALB]), [
FRA
]+23 (4-[ALB]), [
FRA
]+30 (7-[TP]), [
FRA
]x7/[TP], and [
FRA
]x3/[GLB], r was, respectively, 0.616, 0.612, 0.595, 0.589, 0.582, 0.581 and 0.478. In 24 patients with
NIDDM
whose [ALB] is either above 4.5 g/dl or below 3.5 g/dl, r between uncorrected [
FRA
] and [G] was as low as 0.389 without positive correlation. By using our correction formulas of [
FRA
]x33.3/(7.6 [ALB]+[GLB]) or [
FRA
] x 4/[ALB], r was statistically increased, respectively, to 0.769 or 0.788 (P less than 0.05 in both cases) in contrast to no significant increase of r by other formulas being at 0.598, 0.556, 0.540, 0.562 and 0.121. Based on these analyses, it is concluded that our correction formula of [
FRA
] by [FRAc]=[
FRA
]x33.3/(7.6 [ALB]+[GLB]) accurately reflects [G] in
NIDDM
even with hypo- or hyper-albuminemia, and [FRAc]=[
FRA
]x4/[ALB] is useful for practical application for its simplicity.
...
PMID:Correction of fructosamine value for serum albumin and globulin concentrations. 177 12
