Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The data of bicycle ergometry test and echocardiography were studied and compared in patients with postinfarction cardiosclerosis and type II diabetes mellitus without the clinical signs of heart failure. The patients showed the decreased work fitness and the identity of cardiovascular responses to graded exercise, pointing to the common character of the pathogenesis of these diseases. Both groups of the patients manifested the hyperkinetic type of the central hemodynamics as well as the lowering of the rate of diastolic relaxation and the rise of the end diastolic volume of the left ventricle. The intracardiac hemodynamics of coronary heart disease was characterized, in addition, by the reduction of myocardial contractility of the left ventricle due to focal injuries to the myocardial structures, which are more pronounced than in diabetes mellitus.
 ...
PMID:[The role of changes in central and intracardiac hemodynamics in lowering the physical work capacity of patients with ischemic heart disease and diabetes mellitus]. 259 86

Currently identified a large number of biomarkers that are closely linked with the development of chronic heart failure, some of which are clusterin and fractalkine. Accordingly, the purpose of our study was - to evaluate the role of clusterin and fractalkine in progression of chronic heart failure in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity. We investigated 71 patients with postinfarction cardiosclerosis, type 2 diabetes and obesity. All patients with postinfarction cardiosclerosis, diabetes and obesity were divided into groups according to the functional class of chronic heart failure (CHF). It was found that an increase the level of fractalkine and reduced clusterin leads due to the development of systolic dysfunction and heart failure progression in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity. Fractalkine and clusterin play an important role in progression of the heart failure in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity, and this gives them the right to be considered indicators of the severity of CHF.
...
PMID:[New markers of progression of chronic heart failure in patients with myocardial infarction, type 2 diabetes and obesity]. 2569 16