Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Renal replacement therapy of the next decade in Europe will be strongly influenced by certain epidemiological developments, which can be observed in some parts of the world since several years. The overall incidence rates of new patients will rise up to 300 pmp per year, the prevalence rates of patients on treatment will exceed 1000 pmp in some European countries as well as in Japan and in the USA. This is due to a more than proportional increase in the acceptance rates for people older than 65, mostly patients with type II diabetes and hypertensive nephropathy. In Europe, the proportion of patients with NIDDM and diabetic nephropathy shows marked regional differences, which may be more or less important for the development of the whole patient population. Since diabetes as well as hypertensive disease are conditions with high risks for non-renal complications, one cannot expect important improvements in patient survival in spite of technical developments in dialysis therapy.
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PMID:Future evolution of the ESRD patient population--a perspective for the year 2000. 904 43

Hepatitis C virus (HCV) infection is often associated with kidney diseases such as membranoproliferative glomerulonephritis (MPGN), with and without cryoglobulinemia, membranous glomerulonephritis (MGN) or glomerulosclerosis (FSGN). The aim of our study was to determine the frequency of HCV with or without hypertransaminasemia in patients with chronic nephropathy in the predialytic phase. We tested 340 subjects with chronic renal insufficiency (CRI) from our hospital's nephrology outpatient clinic for anti-HCV antibodies. In positive subjects we tested for HCV RNA by PCR method, monitoring, for at least 4 months, common biohumoral parameters including transaminases (AST, ALT). Of the 340 subjects, 46 (13.5%) were positive for HCV RNA, and 8 of these (17%) showed constant alteration of transaminases. HBsAg was found in 8 of the total study population (2.3%), and none of these showed altered transaminases. Type II diabetes mellitus was found in 26% (12/46) of the HCV-RNA positive patients, and in only 12.5% (37/294) of the negative ones. The kidney diseases we found in the 46 HCV-RNA positive patients were: diabetic nephropathy in 11 (23.9%), MPGN in 7 (15.2%), MPGN + cryoglobulinemia in 2 (4.3%), interstitial nephropathy in 4 (8.7%), IgA mesangial GN in 3 (6.5%), hypertensive nephropathy in 2 (4.3%), focal and segmental GN in 1 (2.2%), urologic disease in 4 (8.7%), other (hematological, genetic, iatrogenic) in 3 (6.6%), unknown in 9 (19.6%). Our data show that the most frequent kidney diseases associated with HCV infection were diabetic related nephropathy and MPGN with and without cryoglobulinemia. HCV infection had a positive association with diabetes. It is interesting to note that in this study population the hepatitis C concomitant to kidney disease was unusually mild: only 4 of the 46 subjects (9%) showed clinical, biohumoral and ultrasound evidence of cirrhosis.
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PMID:Hepatitis C and kidney disease. 1793 31

This review presents data on end-stage renal disease (ESRD) due to diabetes (ESRD-DM) from populations of several racial/ethnic groups and regions; it also identifies factors that may explain differences in risk of ESRD-DM among these groups. Diabetes is a major cause of ESRD in several developed countries, including the United States, England, and Australia. However, in these countries, the incidence is much higher for some groups, such as Blacks and Native Americans in the United States, Blacks and Indo-Asians in England, and indigenous populations in Australia. Despite the worldwide increase in the prevalence of diabetes, in some regions such as South Africa and Brazil, the rates of ESRD attributed to hypertension and glomerulonephritis are even higher than rates attributed to diabetes. High prevalence of accelerated/ malignant hypertension and infection-related glomerulonephritis in addition to a higher risk of early death from diabetes might partially explain the predominance of ESRD attributed to hypertensive nephropathy and glomerulonephitis in South Africa and Brazil. These data call attention to the need to develop more effective strategies to prevent type 2 diabetes and thereby reduce the racial/ethnic gap in ESRD-DM. A greater emphasis on hypertension and diabetes control, particularly in racially and economically disadvantaged populations, is also necessary.
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PMID:End-stage renal disease due to diabetes in racial/ethnic minorities and disadvantaged populations. 1948 75