Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Type 2 diabetes mellitus and associated long-term complications have become a significant health problem in adolescents. We report a 16-year-old girl with poorly controlled type 2 diabetes mellitus who had recurrent necrobiosis lipoidica diabeticorum associated with venous insufficiency.
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PMID:Recurrent necrobiosis lipoidica diabeticorum associated with venous insufficiency in an adolescent with poorly controlled type 2 diabetes mellitus. 1218 29

Fourteen patients with chronic venous insufficiency (CVI) of the lower extremities, class 0-4 according to the CEAP (1995) were examined for microcirculation (MC) and effect of detralex, using biomicroscopy of the conjunctival vessels and capillaroscopy of the nail matrix, with detailed computed morphometry. In 7 patients, CVI was associated with truncal arterial hypertension and in 5 with type 2 diabetes mellitus. It has been established that in CVI patients, there were remarkable disorders of MC and regional circulation. In addition to regression of the clinical manifestations of CVI, administration of detralex given in courses to 12 patients noticeably refined both regional circulation in the lower extremities and systemic MC, marked by abatement of perivascular edema, an increase in the number of the functioning microvessels and flow acceleration in them. Also, there was marked the lowering of intramuscular red blood cell aggregation.
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PMID:[Microcirculation end effect of detralex in patients with chronic venous insufficiency of the lower extremities]. 1465 34

We present the case of a patient with severe obesity, type 2 diabetes mellitus, hypertension, and chronic venous insufficiency, as well as several vascular ulcers in the right extremity with complex clinical course. The importance of the treatment and follow-up of these vascular ulcers in primary care is essential to achieve healing or improvement. Because primary care centers can provide easy access and daily evaluation -if required-, the clinical course of vascular ulcers can be more favorable in this setting than in the hospital setting, where appointments are less frequent. In our case, the patient required several changes of treatment; at all times, the importance of controlling all the cardiovascular risk factors was explained to the patient. The involvement of the patient and his family in the disease, as well as follow-up in the primary care center, were essential to obtaining improvement.
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PMID:[Patients with vascular ulcers and cardiovascular risk factors. Case reports]. 1768 Nov 21

We report the case of a 73-year-old man with massive swelling of the lower extremities, with a chronic and rather uncommon form of stasis dermatitis - stasis papillomatosis. The patient was also diagnosed with severe heart failure, including dilated cardiomyopathy, hypothyroidism that required a substantial dose of exogenous tyrosine, microcytic and megaloblastic anemia, iron deficiency, and type 2 diabetes. The cause of stasis dermatitis lesions is not completely understood. It may be caused by the allergic reaction to some epidermal protein antigen formation or chronic damage to the dermal-epidermal barrier that makes the skin more sensitive to irritants or trauma. It has, however, been suggested that the term stasis dermatitis should be used to refer only to cases caused by chronic venous insufficiency, which belongs to a group of lifestyle diseases and affects both women and men more and more frequently.
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PMID:Stasis papillomatosis with cardiac complications and vein insufficiency. 2622 26