Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011860 (type 2 diabetes)
 57,723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Obesity both in adults and children has emerged as a worldwide epidemic. Obesity is associated with an increased risk of a number of comorbidities including type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea, certain types of cancer, degenerative joint disease, non-alcoholic fatty liver disease, reflux esophagitis, stroke, coronary heart disease, venous stasis ulcers, cholelithiasis, erectile dysfunction and polycystic ovary syndrome. It is now generally accepted that bariatric surgery procedures induce long-term weight loss and offer resolution or dramatic improvement in numerous comorbidities of obesity, including type 2 diabetes mellitus, hypertension and dyslipidemia. These effects mainly arise from endocrine changes resulting from the gastrointestinal surgical procedures. The aim of this short review was to evaluate the pros and cons of bariatric surgery for morbid obesity seen from the perspective of a practicing endocrinologist.
 ...
PMID:The pluses and minuses of bariatric surgery for morbid obesity: An endocrinological perspective. 2290 56

A 60-year-old man with a history of hypertension, type 2 diabetes, and reflux esophagitis was admitted to our hospital with hemoptysis, dyspnea, and leg edema. We diagnosed him with adult IgA vasculitis based on the presence of purpura, elevated serum IgA fibronectin complexes, pathophysiological findings, a skin biopsy showing leukocytoclastic vasculitis, and immunofluorescence studies demonstrating granular IgA and C3 deposits in the blood vessel wall. He showed concurrent cardiopulmonary involvement without involvement of the gastrointestinal system and kidneys, which are commonly affected in IgA vasculitis patients. Following treatment with prednisolone, the patient recovered with improvement in cardiopulmonary manifestations.
 ...
PMID:IgA Vasculitis with Simultaneous Cardiopulmonary Involvement. 2922 70

The role of surgical intervention in patients with diabetic gastroparesis is unclear. We report a case of a 37-year-old man with a history of recurrent episodes of vomiting and long-standing type 2 diabetes mellitus. Esophagogastroduodenoscopy did not reveal any findings of reflux esophagitis or obstructive lesions. A gastric emptying time scan showed prolonged gastric emptying half-time (344 minutes) indicating delayed gastric emptying. Laboratory tests revealed elevated fasting serum glucose and glycosylated hemoglobin (HbA1c, 12.9%) and normal fasting C-peptide and insulin levels. We performed Roux-en-Y reconstruction after subtotal gastrectomy to treat gastroparesis and improve glycemic control, and the patient showed complete resolution of gastrointestinal symptoms postoperatively. Barium swallow test and gastric emptying time scan performed at follow-up revealed regular progression of barium and normal gastric emptying. Three months postoperatively, his fasting serum glucose level was within normal limits without the administration of insulin or oral antidiabetic drugs with a reduced HbA1c level (6.9%). Long-limb Roux-en-Y reconstruction after subtotal gastrectomy may be useful to treat severe diabetic gastroparesis by improving gastric emptying and glycemic control.
 ...
PMID:Long-limb Roux-en-Y Reconstruction after Subtotal Gastrectomy to Treat Severe Diabetic Gastroparesis. 3159 78