Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HLA-DR4 and its subtypes were studied by PCP/SSP, PCR/SSOP, and PCR/RFLP methods in 81 patients with IDDM and 106 normal controls in the Han's nationality Chinese population. The results showed no difference in frequencies of DR4 between the IDDM group and the controls (21.0% vs 17.9%), but DRB1*0405, as a subtype Dw15, was significantly associated with IDDM susceptibility (58.8% vs 21.1%, RR = 2.67, P < 0.05). In a family with 2 IDDM patients, it has been found the haplotype DRB1*0405-DQB1*0302 was to be cosegregated with IDDM. It was suggested that DW15 subtype might be associated with IDDM in Chinese because of linkage disequilibrium with DQw8 (DQB1*0302). As an additional evidence, the findings above mentioned may account for the different association of different DR4 subtypes with IDDM in various ethnic groups.
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PMID:[Study on the association of HLA-DR4 with IDDM susceptibility in a Chinese population]. 1045 53

The aim of this study was to evaluate the metabolic effects of 12-week honey consumption on patients suffering from type 1 diabetes mellitus (DM). This was a randomized crossover clinical trial done in the National Institute for Diabetes and Endocrinology, Cairo, Egypt. Twenty patients of both sexes aged 4-18 years with type 1 DM and HbA1C<10% participated in the study. They were randomized into two equal groups (intervention to control and control to intervention). The dietary intervention was 12-week honey consumption in a dose of 0.5 mL/kg body weight per day. The main outcome measures were serum glucose, lipids, and C-peptide, and anthropometric measurements. None of participants were lost in follow-up. The intervention resulted in significant decreases in subscapular skin fold thickness (SSFT; P=.002), fasting serum glucose (FSG; P=.001), total cholesterol (P=.0001), serum triglycerides (TG; P=.0001), and low-density lipoprotein (P=.0009), and significant increases in fasting C-peptide (FCP; P=.0004) and 2-h postprandial C-peptide (PCP; P=.002). As possible long-term effects of honey after its withdrawal, statistically significant reductions in midarm circumference (P=.000), triceps skin fold thickness (P=.006), SSFT (P=.003), FSG (P=.005), 2-h postprandial serum glucose (P=.000), TG (P=.003), and HbA1C (P=.043), and significant increases in FCP (P=.002) and PCP (P=.003) were observed. This small clinical trial suggests that long-term consumption of honey might have positive effects on the metabolic derangements of type 1 DM.
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PMID:Metabolic effects of honey in type 1 diabetes mellitus: a randomized crossover pilot study. 2325 46